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1、聯(lián)合降壓治療老年高血壓療效觀察［摘要］目的：探討聯(lián)合應(yīng)用降壓藥治療老年高血壓的療效。方法：采取隨機、平行分組、對照方法將患者分為三組,甲組40例，單用非洛地平緩釋片(鈣拮抗劑)10mg/d；乙組44例，非洛地平緩釋片5mg/d+^沙坦(血管緊張素II受體阻滯劑ARB)80mg/d；丙組46例，非洛地平緩釋片5mg/d+厄貝沙坦氫氯囈嗪150mg/do結(jié)果：治療8周后，丙組收縮壓(SBP)和舒張壓(DBP)達標率分別為60.9%和95.6%,較甲組SBP達標率(15.0%、80.0%)和乙組(9.1%、68.2%)高，差異有統(tǒng)計學(xué)意義(P<0.05或0.01)o甲組總不良反應(yīng)發(fā)生率(2
2、7.5%,11/40)與乙組(4.5%,2/44)、丙組(8.7%,4/46)比較，P均V0.05o結(jié)論:鈣拮抗劑聯(lián)合ARB復(fù)合劑(ARB+小劑量利尿劑)治療老年高血壓療效理想，且不良反應(yīng)低。［關(guān)鍵詞］高血壓抗高血壓藥物；厄貝沙坦；利尿藥［中圖分類號］R544.1［文獻標識碼］B［文章編號］1673-7210(2011)02(c)-061-02Effectobservationoftreatingagepatientswithhypertensionbymulti-ontihypertensivedrugsHAODejingl,LUOLi2,TANGChunyanl,QUJianhu
3、a3［1.EmergencyCenter,No.4ClinicalHospitalAttachedtoJilinUniversity(FAWHospital),Changchun130011,China；2.1CU,No.4ClinicalHospitalAttachedtoJilinUniversity(FAWHospital),Changchun130011,China；3.PharmacyDepartment,No.4ClinicalHospitalAttachedtoJilinUniversity(FAWHospital),Changchun130011,China][Abs
4、tract]Objective：Todiscusstheeffectoftreatingagepatientswithhypertensionbyusingmulti-antihypertensivedrugs.Methods：Thepatientsweredividedintothreegroupsrandomly.Therewere40patientsingroupA；eachoneinthisgrouptookthesingledrugfelodipine(calciumantagonist)10mg/d.Therewere44patientsingroupB；eachonei
5、nthisgrouptookthedrugfelodipine(calciumantagonist)5mg/dandvalsartan(angiotensinIIreceptorblocker,ARB)80mg/d.Therewere46patientsingroupC；eachoneinthisgrouptookthedrugfelodipine(calciumantagonist)5mg/d,Irbesartanandhydrochlorothiazide150mg/d?Results：Afterthetreatmentof8weeks,thepatients'SBPingrou
6、pCwaslowerthan140mmHgandDBPwaslowerthan90mmHg.Theidealratewas60.9%and95.6%respectively.TheywerehigherthantheratesofSBPandDBPingroupA(15.0%,80.0%)andthatinGroupB(9.1%,68.2%),allP<0.05.AdversereactionratesingroupB(4.5%,2/44)andingroupC(8.7%,4/46)werelowerthanthatingroupA(27.5%,11/40),allP<0.05.Co
7、nclusion：TheeffectispositiveintreatingagepatientswithhypertensionbycombiningcalciumantagonistwithARBcompound(ARBpluslowdoseofdiuretic)andtheadversereactionrateislower.[Keywords]Hypertension；Antihypertensivedrugs；Irbesartan；Diureti
