高強度窄譜藍光治療面部尋常性痤瘡臨床觀察

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1、高強度窄譜藍光治療面部尋常性瘞瘡臨床觀察［摘要］目的：觀察高強度窄譜藍光治療面部尋常性瘞瘡的療效。方法：應(yīng)用波長為405?420nm的高強度窄譜藍光治療93例面部尋常性痙瘡患者，每周2次，共治療8次。計數(shù)患者炎性皮損（丘疹、膿皰、結(jié)節(jié)和囊腫）、非炎性皮損（粉刺）及皮損總數(shù)來計算改善率；觀察患者治療前后皮膚黑素指數(shù)、紅斑指數(shù)、皮脂分泌及角質(zhì)層含水量的變化情況。結(jié)果：治療結(jié)束時，總有效率為82.80%0非炎性及炎性皮損平均改善率分別為51.67%和6&90%；患者面部紅斑指數(shù)及皮脂分泌顯著降低，而黑素指數(shù)及角質(zhì)層含水量與治療前比較無顯著變化。隨訪3個月，總有效率與治療結(jié)束時相比差異無統(tǒng)計學(xué)意義

2、。結(jié)論：高強度窄譜藍光治療面部尋常性瘞瘡療效顯著，且可以減輕皮膚紅斑、減少皮脂分泌。［關(guān)鍵詞］藍光；尋常性痙瘡；黑素指數(shù)；紅斑指數(shù)；皮脂［中圖分類號1R758.73［文獻標(biāo)識碼］A［文章編號］1008-6455（2007）10-1400-04Treatmentoffacialacnevulgarisbyahigh-intensity,narrow-bandbluelightsourceLIUMeil,LIYuan-hong1,WUYanl,D0NGGuang-hui2,XUYuan-yuan1,HEChun-di1,CHENHong-Duol(1.DepartmentofDermatolo

3、gyofNO.1Hospital,KeyLaboratoryofImmunodermatologyofMinistryofHea1th,ChinaMedicalUniversity,Shenyang110001,Liaoning,China；2.DepartmentofBiostatistics,ChinaMedicalUniversity)Abstract:ObjectiveToobservetheefficacyofphototherapywithahigh-intensity,narrow-bandbluelightsourceinpatientswithfacialacnevulg

4、aris?MethodsNinty-threepatientswithfacialacnevulgarisweretreatedwiththe405-420nmbluelight,twiceweeklyfor4weeks.Thenumberofinflammatorylesions(papules,pustules,nodulesandcysts),non-inflammatorylesions(comedones)andthetotalnumberwerecountedtoevaluatetheimprovement?Thechangesofskinmelaninindex,erythe

5、maindex,sebumsecretionrate,corneumwatercontentwereobservedbeforeandaftertreatment.ResultsAfterthetreatment,82?80%ofthepatientsgotmorethan60%improvement?Meonpercentageimprovementsafterthefinaltreatmentinnon-inflammatoryandinflammatorylesionswere51.67%and68.90%,respectively.Atthe3-monthfollow-upvisi

6、t,theglobalimprovementdidnotchangealot.Erythemaindex,sebumsecretiondecreasedsignificantlyafterthefinaltreatment.However,melaninindexandcorneumwotercontentremainedatthelevelbeforethetreatment?ConclusionBluelighttreatmentiseffectiveforpatientswithfacialacnevulgaris?Itcanalsorelievetheskinerythemaand

7、reducesebumsecretion.Keywords:bluelight；acnevulgaris；melaninindex；erythemaindex；sebum痙瘡是一種累及毛囊皮脂腺的慢性炎癥性皮膚病，好發(fā)于皮脂溢出部位，青少年發(fā)病率高。如果不進行恰當(dāng)治療，嚴(yán)重者會遺留永久性瘢痕，影響患者的外貌美觀及生活質(zhì)量。由于系統(tǒng)應(yīng)用維甲酸或抗生素治療會發(fā)生一系列不良反應(yīng)，加之隨著痙瘡丙酸桿菌對抗生素耐藥性的增加，為尋常