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1、檢驗醫(yī)學與臨床２０１６年８月第１３卷第１６期LabMedClin，August２０１６，Vol．１３，No．１６·２２６７··論著·新生兒出生早期血清降鈣素原濃度變化規(guī)律及其影響因素分析１２１１２許蔓春，廖揚，任廣立，馬恒顥，石玉玲（廣州軍區(qū)廣州總醫(yī)院：１．小兒科，２．檢驗科５１００１０）摘要：目的探討新生兒出生早期血清降鈣素原（PCT）變化規(guī)律及常見圍產(chǎn)因素對PCT水平的影響。方法分析２０１２年１月至２０１４年１２月該院收治的無感染健康新生兒４７０例，其中足月兒２４０例，早產(chǎn)兒２３０例，分析其出生一周內血清PCT水平，采用多元線性回歸分析胎齡等常見圍產(chǎn)因素對PCT水平的
2、影響。結果足月兒及早產(chǎn)兒PCT水平在出生時極低，出生后１２h內均略上升，并分別于出生后≥１２～２４h及≥２４～４８h達峰值，隨后均逐步下降，最后兩者分別在出生后約７２h后及９６h后降至正常嬰兒水平。多元回歸分析提示早產(chǎn)兒的PCT水平與樣本檢測時間（出生日齡）及其胎齡大小相關，足月兒PCT水平僅與出生日齡相關。結論足月兒及早產(chǎn)兒在出生早期PCT生理波動規(guī)律有所不同，且早產(chǎn)兒胎齡與PCT水平相關，該發(fā)現(xiàn)對于新生兒早發(fā)細菌感染的診斷與鑒別診斷、指導臨床合理使用抗菌藥物有重要臨床意義。關鍵詞：降鈣素原；足月兒；早產(chǎn)兒；胎齡；圍產(chǎn)因素DOI：10．3969／j．issn．1672-
3、9455．2016．16．012文獻標志碼：A文章編號：１６７２-９４５５（２０１６）１６-２２６７-０３Analysisofchangesofprocalcitioninandinfluencingfactorsoninfantsduringtheearlyneonatalperiod１２１１２XUManchun，LIAOYang，RENGuangli，MAHenghao，SHIYuling（１．DepartmentofPediatrics；２．DepartmentofClinicalLaboratory，GeneralHospitalofGuangzhouMilita
4、ryCommand，Guangzhou，Guangdong５１００１０，China）Abstract：ObjectiveToinvestigatechangesofprocalcitionin（PCT）andinfluencingfactorsoninfantsduringtheearlyneonatalperiod．MethodsAtotalof４７０healthyneonatesincluding２４０termnewbornsand２３０pretermnewbornswereenrolledfromJanu-ary２０１２toDecember２０１４．Andthele
5、velofPCTbetweenbirthandthefirstweekoflifewasanalyzed．GestationalageandothercommonperinatalvariableswereinvestigatedtoseehowthefactorsinfluencedPCTconcentrationbymultivariableanalysis．ResultsLevelsofPCTwerelowestatbirthintermandpretermnewbornsandthenincreasedslightlywithin１２hafterbirth，whi
6、chgraduallyreachedthepeakvaluesat≥１２－２４hand≥２４－４８hafterbirth，andthendeclinedslowlytonormallevelsat７２hand９６hafterbirth．respectivelyinmultivariableanalysis，gestationalageandneonatalageinfluencedPCTconcentrationinde-pendentlyinpretermnewborns，andonlyneonatalagewasassociatedwithPCTvaluesinter
7、mnewborns．ConclusionTherearedif-ferentchangingrulesofPCTlevelintermandpretermbabiesduringtheearlyneonatalperiod，andgestationageisrelatedwithPCTconcentrationinpretermbabies．Thefindingsarehelpfulindetectingearly-onsetneonatalbacterialinfectionandrationaluseofantibioti
