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1、萬(wàn)方數(shù)據(jù)國(guó)際眼科雜志2007年12月第7卷第6期電話(huà):029-.82245172電子信箱:UO.2000@163.COrn年齡相關(guān)性黃斑變性的治療研究新進(jìn)展張歆,任百超·文獻(xiàn)綜述·作者單位:(710004)中國(guó)陜西省西安市,西安交通大學(xué)第二附屬醫(yī)院眼科作者簡(jiǎn)介:張歆,女,在讀碩士研究生。通訊作者:任百超.rbc369@yahoo.conl.cn收稿日期:2007.10-26修回日期:2007—11.12Recentadvanceofthestudyontreatmentforage—relatedmaculardegenerationXinZha
2、ng,Bai-ChaoRenDepartmentofOphthalmology,theSecondAffiliatedHospitalofXi’anJiaotongUniversity.Xi’an710004,ShaanxiProvince,ChinaCorrespondenceto:Bai—ChaoRen.DepartmentofOphthalmology,theSecondAffiliatedHospitalofXi’anJiaotongUniversity.Xi’an710004.ShaanxiProvince.China.rbc369@y
3、ahoo.com.cnReeeived:2007.10.26Accepted:2007.11.12Abstract·Age—relatedmaculardegeneratiOniSaseveremacuIardiseaseofwhichtheincidenceincreaseswiththepatients’agegrowing.ThisdiseaseischaracterizedbyprogressivedeteriorationoftheretinaIpigmentepitheliumandmacuIa.Ieadingtoirreversib
4、ledecreaseorIOSSofcentraIvision.Recently.a(chǎn)greatmanyofrandomizedclinicaItriaIShavebeenobservedfortheevaluationofthetreatmentofvarioustypesofage—relatedmaculardegeneration(ARMD)especiaIIYneovascuIarARMD,suchasphotodynamictherapy,drugtreatment,radiotherapy,laserphotocoagulation,
5、surgicalintervention,transpupillarythermotherapyandtraditionaIChinesemedicine.Thepresentpaperreviewstheprogressinthetreatmentofage—relatedmaculardegeneration.·KEYWORDS:age—relatedmaculardegeneration;choroidalneovascuIarization:IiteraturereviewZhangX,RenBC.Recentadvanceofthest
6、udyontreatmentforage—relatedmacLdaFdegeneration.In£JOphthalmol(t知西YankeZazhi).2007;7(6):1674—1676摘要年齡相關(guān)性黃斑變性是一種隨年齡增長(zhǎng)而發(fā)病率逐漸上升的黃斑部疾病。主要由視網(wǎng)膜色素上皮細(xì)胞和視網(wǎng)膜退行性變而引起的不可逆性的中心視力下降或喪失。近年來(lái),對(duì)多種類(lèi)型年齡相關(guān)性黃斑變性尤其是新生血管型(age·relatedmaculardegeneration,ARMD)的治療已經(jīng)進(jìn)行了大量的多中心的臨床實(shí)驗(yàn)觀(guān)察,涌現(xiàn)出光動(dòng)力療法、藥物治療、放射治療、激光
7、光凝、黃斑下手術(shù)、經(jīng)瞳孔溫?zé)嶂委?、中醫(yī)藥治療等方法,本文就ARMD目前有關(guān)的治療方法及其進(jìn)展做一綜述。關(guān)鍵詞:年齡相關(guān)性黃斑變性;脈絡(luò)膜新生血管;綜述文獻(xiàn)張歆,任百超.年齡相關(guān)性黃斑變性的治療研究新進(jìn)展.國(guó)際眼科雜志,2007;7(6):1674—1676O引言年齡相關(guān)性黃斑變性(age—relatedmaculardegeneration,ARMD),是一種隨年齡增長(zhǎng)而發(fā)病率逐漸上升的黃斑疾病。主要由視網(wǎng)膜色素上皮(RPE)細(xì)胞和視網(wǎng)膜退行性變而引起的不可逆性的中心視力下降或喪失。該疾病是兩方國(guó)家老年人低視力和致盲的首要原因。隨著我國(guó)經(jīng)濟(jì)文化、
8、衛(wèi)生條件的提高和改善,發(fā)病率也隨之上升。一項(xiàng)?關(guān)于中國(guó)陜西省農(nóng)村ARMD調(diào)查顯示,在當(dāng)?shù)?0~49歲年齡組人群中ARMD患病率為0.47