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1、MovementDisordersVol.7,No.2,1992,pp.153-15801992MovementDisorderSocietyCerebrospinalFluidAntibodiestoCoronavirusinPatientswithParkinson’sDiseaseEnricoFazzini,*JohnFleming,andStanleyFahnDepartmentofNeurology,CollegeofPhysiciansandSurgeons,Columbia-Presbyter
2、ianMedicalCenter,NewYork,NewYork;*DepartmentofNeurology,UniversityofCaliforniaatLosAngeles,LosAngeles,California,U.S.A.Summary:TheetiologyofParkinson’sdiseaseremainsunknown,andasearchforenvironmentalagentscontinues.In1985,Fishman(10)inducedinfectionoftheba
3、salgangliabyacoronavirusinmice.Althoughcoronavirusisrecognizedprimarilyasarespiratorypathogeninhumans,itsaffinityforthebasalganglialedustoinvestigateitspossibleroleinhumanParkinson’sdisease.Thecere-brospinalfluidofnormalcontrols(CTL)(n=18),andpatientswithP
4、arkin-son’sdisease(PD(n=20)andotherneurologicaldisease(OND)(n=29)wasanalyzedinablindedmannerbyenzyme-linkedimmunosorbentassay[mea-surementsinopticaldensity(OD)units]forantibodyresponsetofourcoro-navirusantigens:mousehepatitisvirusJHM(J)andA59(A),andhumanco
5、ronavirus229E(E)andOC43(0).WhencomparedwithCTL,PDpatientshadanelevated(p<0.05)meanODresponsetoJ(0.0856VS.0.0207)andA(0.1722vs.0.0636).Response(p>0.05)to0(0.0839vs.0.0071)wasgreaterthanthattoE(0.1261vs.0.0743).WhencomparedtoOND,PDpatientshadanelevatedmeanOD
6、responsetoJ(0.0856vs.0.0267,p<0.05).Responses(p>0.05)toA(0.1722vs.0.0929)and0(0.0839vs.0.0446)weregreaterthanthattoE(0.1261vs.0.0946).TheseresultssuggestthattheremaybeanassociationbetweencoronavirusandPD.KeyWords:Parkinson’sdiseas+Coronavirus-Environmental
7、factors.TheetiologyofParkinson’sdisease(PD)remainslatedfromhumansinthemid-1960sinpatientswithunknown,althoughitisprobablethatthereexistsathecommoncold(5).Thereareatleast10speciesmultitudeofenvironmentalagentsthathaveincom-thathavebeenidentified,includinghu
8、mancorona-monaselectiveaffinityforthesubstantianigra(1-virus(HCV),murinehepatitisvirus(MHV),bovine3).Virusesthathavebeenimplicatedincausingen-coronavirus(BCV),haemagglutinatingencephalo-cephalitisandparkinson
