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1、Abstracts/BiolBloodMarrowTransplant23(2017)S18–S391S51withamismatchindonor-recipientinheritedciHHV-6statusgroupand10%(37/382)diedinthenot-testedgroup(P=.22).hadincreasedriskforaGVHDgrades2-4(Table1).Identify-Inunivariableanalyses,pre-HCTrespiratoryvirusi
2、nfectioningtheimpactofdualpositivityforinheritedciHHV-6ondidnotnegativelyimpactmortalityinallpatientsandintheoutcomeswaslimitedbysmallnumbers.allogeneicHCTsubset.Among,allogeneicHCTrecipients,Conclusions:ThisisthelargeststudyofoutcomesafterHCTpre-HCTresp
3、iratoryvirusinfectionofindividualviralgroupswithdonorsorrecipientsharboringinheritedciHHV-6.Thesealsodidnotshowanegativeimpactondaysaliveandoutpatientsdidnothavestatisticallysigni?cantdifferencesinofhospital(meandifferencetoasymptomatic/not-testedpa-over
4、allsurvivalcomparedtoHCTpairswithoutinheritedtients:PCRpositivesymptomatic?1.8,95%CI,?6.1to2.5;ciHHV-6.Donor-recipientmismatchininheritedciHHV-6PCRnegativesymptomatic?3.2,95%CI,?6.9to.5).ResultsstatusincreasedriskforaGVHDgrades2-4.Furtherstudiesremainedn
5、on-signi?cantafteradjustingforothersigni?-areneededtovalidatethese?ndingsandidentifypotentialcantriskfactors(stemcellsourceandconditioningregimen).mechanismsleadingtoalloreactivity.Conclusion:Thisstudysuggeststhatcurrentrecommenda-tionstodelayHCTforRSV,H
6、MPV,in?uenza,adenovirusandPIVareeffective.Thepresenceofpre-transplantHRVandHCoV,forwhichdelayisnotroutinelyrecommended,may44nothaveanegativeimpactontransplantoutcomeinadultImpactofRespiratoryVirusInfectionbeforeHCTrecipients.Furtherdataareneededtode?neth
7、erela-HematopoieticCellTransplantation(HCT)onPost-tivesigni?canceofupperversuslowerrespiratorytractviralTransplantOutcomesinAdultsinthePCREra:Doinfections.RhinovirusandCoronavirusInfectionsMatter?Yae-JeanKim1,2,AlpanaWaghmare1,3,4,JaneM.Kuypers5,KeithR.J
8、erome1,5,StevenA.Pergam6,7,8,HuXie1,WendyM.Leisenring1,ChikaraOgimi4,JanetA.Englund3,4,45MichaelJ.Boeckh6,9.1FredHutchinsonCancerResearchMaribavirforTreatmentofCytomegalovirusInfections2DepartmentofPediatrics,SamsungCenter
