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1、AcceptedManuscriptDisulfiramcaninhibitMERSandSARScoronaviruspapain-likeproteasesviadifferentmodesMin-HanLin,DavidC.Moses,Chih-HuaHsieh,Shu-ChunCheng,Yau-HungChen,Chiao-YinSun,Chi-YuanChouPII:S0166-3542(17)30610-1DOI:10.1016/j.antiviral.2017.12.015Reference:AVR4
2、217Toappearin:AntiviralResearchReceivedDate:31August2017RevisedDate:11November2017AcceptedDate:20December2017Pleasecitethisarticleas:Lin,M.-H.,Moses,D.C.,Hsieh,C.-H.,Cheng,S.-C.,Chen,Y.-H.,Sun,C.-Y.,Chou,C.-Y.,DisulfiramcaninhibitMERSandSARScoronaviruspapain-li
3、keproteasesviadifferentmodes,AntiviralResearch(2018),doi:10.1016/j.antiviral.2017.12.015.ThisisaPDFfileofanuneditedmanuscriptthathasbeenacceptedforpublication.Asaservicetoourcustomersweareprovidingthisearlyversionofthemanuscript.Themanuscriptwillundergocopyedit
4、ing,typesetting,andreviewoftheresultingproofbeforeitispublishedinitsfinalform.Pleasenotethatduringtheproductionprocesserrorsmaybediscoveredwhichcouldaffectthecontent,andalllegaldisclaimersthatapplytothejournalpertain.ACCEPTEDMANUSCRIPTDisulfiramcaninhibitMERSan
5、dSARScoronaviruspapain-likeproteasesviadifferentmodes1213Min-HanLin,DavidC.Moses,Chih-HuaHsieh,Shu-ChunCheng,Yau-Hung23,1,Chen,Chiao-YinSun*,Chi-YuanChou*1DepartmentofLifeSciencesandInstituteofGenomeSciences,NationalYang-MingUniversity,Taipei112,Taiwan2Departme
6、ntofChemistry,TamkangUniversity,Tamsui251,Taiwan3DepartmentofNephrology,Chang-GungMemorialHospital,Keelung204,TaiwanRunningtitle:Analcohol-aversivedrug,disulfiram,caninhibitcoronaviralpapain-MANUSCRIPTlikeprotease._____________________*Correspondenceinformation
7、forDr.Chi-YuanChou.Address:155Li-NongSt.,Sec.2,Taipei112,Taiwan,R.O.C.Phone:+886-2-28267168.FAX:+886-2-28202449.E-mail:cychou@ym.edu.twandDr.Chiao-YinSun.Address:222Mai-ChinRd.,Keelung204,Taiwan,R.O.C.Phone:+886-2-24313131ext.3170.FAX:+886-2-24335342.E-mail:fis
8、h3970@gmail.com.ACCEPTED1ACCEPTEDMANUSCRIPTAbbreviationsproTheabbreviationsusedarecoronavirus(CoV),mainprotease(M),diethyldithiolcarbamate(DDC),deubiquitination(DUB),MiddleE
