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1、CORRESPONDENCEJamesE.Loyd,M.D.syndromehumancoronavirus(SARS-HCoV)in2002–2003TinaV.Hartert,M.D.,M.P.H.reintroducedtheCoronaviridaefamily.In2004and2005,JoshuaC.Denny,M.D.,M.S.JonathanA.Kropski,M.D.respectively,twonewcoronaviruseswerediscovered:NL63andVanderbiltUniversitySchoolofMe
2、dicineHKU1(2,3).TheCoronaviridaefamilyisfurthersubclassi?edintoNashville,Tennesseetwogenera:thealphacoronaviruses(HCoV-229EandHCoV-NL63)andbetacoronaviruses(HCoV-HKU1,HCoV-OC43,ReferencesMiddleEastrespiratorysyndrome[MERS]-HCoV,andSARS-HCoV).HCoV-NL63infectioncausesmostlyupperan
3、dattimes1.FingerlinTE,MurphyE,ZhangW,PeljtoAL,BrownKK,SteeleMP,Loydlowerrespiratorytractinfection,community-acquiredpneumonia,JE,CosgroveGP,LynchD,GroshongS,etal.Genome-wideandalsocroupinchildren(4).In2012,anothercoronavirus-associationstudyidenti?esmultiplesusceptibilitylocifor
4、pulmonaryrelatedepidemicoccurred,thistimeintheMiddleEast,whichled?brosis.NatGenet2013;45:613–620.totheidenti?cationoftheMERS-HCoV(5).2.NothI,ZhangY,MaSF,FloresC,BarberM,HuangY,BroderickSM,WadeMS,HysiP,ScuirbaJ,etal.GeneticvariantsassociatedwithA76-year-oldwomanwasadmittedbecause
5、shehadidiopathicpulmonary?brosissusceptibilityandmortality:agenome-experienced4daysoflow-gradefever,dyspnea,andmalaise.Shewideassociationstudy.LancetRespirMed2013;1:309–317.hadnodiscerniblecomorbiditiesandtooknomedications.3.DennyJC,RitchieMD,BasfordMA,PulleyJM,BastaracheL,Ceftr
6、iaxoneandazithromycinwereinitiated,butshortlyafterBrown-GentryK,WangD,MasysDR,RodenDM,CrawfordDC.admission,herrespiratoryfailureworsened,requiringmechanicalPheWAS:demonstratingthefeasibilityofaphenome-widescantodiscovergene-diseaseassociations.Bioinformatics2010;26:ventilation.H
7、erPaO2/FIO2ratiowas70,consistentwithsevereadult1205–1210.respiratorysyndrome(ARDS),whichremainedheronlyfailing4.DennyJC,BastaracheL,RitchieMD,CarrollRJ,ZinkR,MosleyJD,Fieldsystemthroughoutherentirecourse.Shewasturnedprone,andJR,PulleyJM,RamirezAH,BowtonE,etal.Systematiccompariso
8、nofinhalednitricoxidewasadded.phenome-wideassoc
