資源描述：
《冠狀病毒Coronavirusl論文-2016 Clinical Implications of 5 Cases of Middle East Respiratory Syndrome Coronavirus Infection in a South Korean Outbre.pdf》由會員上傳分享，免費在線閱讀，更多相關內容在學術論文-天天文庫。
1、Jpn.J.Infect.Dis.,69,361–366,2016OriginalArticleClinicalImplicationsof5CasesofMiddleEastRespiratorySyndromeCoronavirusInfectioninaSouthKoreanOutbreakJi-YoungRhee1*,GoohyeonHong2,andKyoungMinRyu31DivisionofInfectiousdiseases,DepartmentofMedicine;2DivisionofAllergyandPulmonaryMedicine,Depart
2、mentofInternalMedicine;and3DepartmentofThoracicandCardiovascularSurgery,DankookUniversityHospital,DankookUniversityCollegeofMedicine,Cheonan,SouthKoreaSUMMARY:TheKoreaMiddleEastrespiratorysyndromecoronavirus(MERS-CoV)wasfirstcon-firmedonMay20,2015,withasubsequentoutbreakinSouthKorea.Fivepa
3、tientswithsuspectedMERS-CoAinfectionwereadmittedtoourhospitalduringthisoutbreak.Onepatienthadnomajorsymptomsuponadmission,butpneumoniawasidentifieduponchestradiography.Twopatientsprogressedrapidlytoacuterespiratoryfailureandrequiredventilator-assistedrespiration.Onepatientrequiredextracorp
4、orealmembraneoxygenationtotreatrefractoryhypoxemia,andonepatientdiedofshockwithmultiorganfailure.Allthepatientshadfever,myalgia,leucopenia,normalprocalcitoninlevel,andpneumonia.Importantly,cliniciansshouldtestforpneumoniainallsuspectedpatientswithMERS-CoVinfection,evenintheabsenceofrespira
5、torysymptoms.Thepneumoniausuallyaffectedthelowerlobes.Ashorterincubationperiodwasassociatedwithmoreseverediseaseandgreaterriskofmortality,andtheseverityoffeverpredictedtheprognosisofMERS-CoVinfection-relatedpneumonia.Therefore,incasesoflower-lobepneumoniathatoccurduringanMERS-CoVoutbreakan
6、dareunes-ponsivetoantibiotics,cliniciansshouldconsiderthepossibilityofMERS-CoVinfection.developeddyspneaandcoughdeveloped,andhewasINTRODUCTIONtransferredvialocalClinicC(Yulineuwon)totheInSeptember2012,theMiddleEastrespiratorysyn-SamsungMedicalCenter(HospitalD).Thepossibilitydromecoronaviru
7、s(MERS-CoV)wasfirstreportedinofMERS-CoVinfectionwasfirstconsideredonMaySaudiArabia,in2patientswithseverepneumonia(1).18.Atthattime,thepatientwasisolatedandindividualThisviruscausessporadicinfections,aswellasin-precautionswereimplemented.MERS-CoVinfectiontrafam
