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1、結(jié)論：l.OPG、TRAIL可能分別在骨肉瘤細(xì)胞存活、凋亡機(jī)制中起作用；2.在骨肉瘤中OPG的高表達(dá)可能抑制了TRAIL的表達(dá)，同時(shí)可能與大量腫瘤骨的形成有關(guān)；3.OPG、TRAIL可能與骨肉瘤侵襲轉(zhuǎn)移有關(guān)。關(guān)鍵詞：OPG；TRAIL；骨肉瘤；骨軟骨瘤；免疫組織化學(xué)TheexpressionanditsmeaningofOPGandTRAILinOsteosarcomaAbstractObjective:ThisarticlemainlystudiedtheexpressionofOPGandT
2、RAILinosteosarcomaandosteochondromabyImmunohistochemicalmethods,andpreliminarydiscussionedthepossiblesignificanceandrelevanceofthemintheoccurrenceanddevelopmentofosteosarcoma.Methods:TheexpressionofOPGandTRAILin50casesofosteosarcomaand10casesofosteoc
3、hondromawasdetectedbyImmunohistochemicalSABCmethod,then,SPSS19.0wasusedtoanalyzetheresults;andthus,wecanpreliminarilyexploreitssignificanceandanalyzethecorrelationofthem.Results:LOPGmainlyexpressedinosteosarcomacellcytoplasm,Therewere36caseswereposit
4、ivein50patientswithosteosarcoma,thepositiveratewas72.00%;whileonly2caseswerepositivein10casesofosteochondroma,thepositiveratewas20.00%.Whichhavesignificantdifferencebetweenthetwogroups(P<0.05).TheexpressionofOPGindifferentpathologicaltissuetypingwasn
5、osignificantdifference(P>0.05),However,theexpressionofOPGinthedifferentEnneckingstageswasobviousdifference(P<0.05).2.TRAILmainlyexpressedinthemembraneofosteosarcomacell,Therewere16caseswerepositivein50patientswithosteosarcoma,thepositiveratewas32.00%
6、;while7caseswerepositivein10casesofosteochondroma.thepositiveratewas70.00%.Whichhavesignificantdifferencebetweenthetwogroups(P<0.05).TheexpressionofTRAILwasnosignificantdifferenceindifferentpathologicaltissuetypingandthedifferentEnneckinginstallments
7、inosteosarcoma(P>0.05).3?ThepositiverateofOPGinthetransfergroupofosteosarcomawas93.30%,andinthenon-transfergroupwas58.82%.theexpressionofOPG-positiverateinthetwogroupswassignificantlydifferent(P<0.05).While,thepositiveimmunostainingrateofTRAILinthetr
8、ansfergroupofosteosarcomawas17.39%,andintheon-transfergroupwas31.25%.theexpressionofTRAIL-positiverateinthetwogroupswasdramaticallydifferent(P<0.05).4、OPGandTRAILexpressioninosteosarcomawasnegativelyrelatedandstatisticallysignificant(r=-0.432,P=0.002
