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1、ArchivesofVirologyArchivesofVirology54,345--352(1977)?bySpringer-Verlag1977ExperimentalInfeetionofAdultAxenieRatsWithParker'sRatCoronavirusByP.N.BHATTandR.O.JACOB￥SectionofComparativeMedicine,YaleUniversitySchoolofMedicine,NewHaven,Connecticut,U.S.A.With5F
2、iguresAcceptedMarch31,1977SummaryThepathogenesisofParker'sRatCoronavirus(PRCV)wasstudiedinaxenieCDrats.Threetofour9to10weekoldratswereeuthanizeddailyforeightdaysafterintranasalinoculation.Ratsremainedfreeofclinicaldisease.Viruswasre-coveredfromthenasophary
3、nxandtracheaaftertwenty-fourhoursandfromthelungbydaythreebutwasnotdetectedinrespiratorytract,aftersevendays.Viralantigenwasdetectedbyindirectimmunofluoresecnceinthemueosalepi-theliumofupperrespiratorytractandinpulmonaryalveolarseptaefromdaytwotosixpostinoc
4、ulation.Acuterhinitisdevelopedbydaytwoandwasassociatedwithmildfocalnecrosisofrespiratorymucosalepithelium.Mildnonsuppurativetracheitisandmultifocalinterstitialpneumoniaappearedbydayfiveandper-sistedthroughdayeight.Dacryoadeaitisdidnotoccur,sialoadenitiswas
5、detectedinonlythreeratsandviruswasrecoveredfromonlyonesubmaxillarysalivarygland.ThisexperimentindicatesthatPRCVcanbeaprimarypathogenfortherespiratorysystemofadultrats.Incontrasttosialodacryoadenitis(SDA)virusthetropismofPRCVforsalivaryandlacrimalglandsislo
6、w.IntroductionCoronavirusinfectioniscommoninlaboratoryratsandtwoantigenicallyrelatedviruses,sialodacryoadenitisvirus(SDAV)andParker'sratcoronavirus(PRCV),havebeenisolatedfromnaturally-infectedrats(2,7).SDAVcausessevereself-limitingsialodacryoadenitisinnatu
7、rally-infectedorexperimentally-inoculatedadultrats(4,5)andrecentevidenceindicatesthatSDAVisassociatedwithnaturally-occurringkeratoeonjunetivitisinrats(6).PRCVwasoriginallyisolatedfromthelungsofratswithahighincidenceofcomplement-fixing(CF)23*34:6P.N.BHA~'Ta
8、ndR.0.JACOB￥:antibodytomousehepatitisvirus(MHV)(7).IncontrasttoSDAV,naturalin-fectionwithPRCVisreportedlyasymptomaticinadults,butexperimentally-inoculatedneonatesdevelopedlethalinterstitialpneumonia(7).Thisre
