資源描述：
《冠狀病毒Coronavirusl論文-2018 Inactivation of Ebola virus and Middle East respiratory syndrome coronavirus in platelet concentrates and plasma by.pdf》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、ORIGINALRESEARCHInactivationofEbolavirusandMiddleEastrespiratorysyndromecoronavirusinplateletconcentratesandplasmabyultravioletClightandmethyleneblueplusvisiblelight,respectively1223MarkusEickmann,UteGravemann,WiebkeHandke,FrankTolksdorf,322StefanReichenberg,ThomasH.Muller,€andAxelSeltsam
2、iddleEastrespiratorysyndromecoronavi-BACKGROUND:Ebolavirus(EBOV)andMiddleEastrus(MERS-CoV)andEbolavirus(EBOV)respiratorysyndromecoronavirus(MERS-CoV)haveareemerginginfectiousdiseasesthatcur-beenidentifiedaspotentialthreatstobloodsafety.ThisMrentlyarenotconsideredahighormoder-studyinvestig
3、atedtheefficacyoftheTHERAFLEX1,2atepriorityforbloodtransfusionsafetyandavailability.UV-PlateletsandTHERAFLEXMB-PlasmapathogenMostcasesofMERS-CoVinfectionhavearisenintheMid-inactivationsystemstoinactivateEBOVandMERS-CoVdleEast(particularlySaudiArabia)andintheRepublicofinplateletconcentrate
4、s(PCs)andplasma,respectively.3Korea,buttwodocumentedcaseswereobservedintrav-STUDYDESIGNANDMETHODS:PCsandplasma4elerstotheUnitedStates.ThissuggeststhatMERS-CoVwerespikedwithhightitersofcellculture–derivedEBOVmightcontinuetoemergeinWesterncountriesviatrans-andMERS-CoV,treatedwithvariousligh
5、tdosesofmissionbypersonstravelingtoorreturningfromaffectedultravioletC(UVC;THERAFLEXUV-Platelets)orareas.ThereisnoevidencetodatethatMERS-CoVmethyleneblue(MB)plusvisiblelight(MB/light;THERAFLEXMB-Plasma),andassessedforresidualviralinfectivity.ABBREVIATIONS:EBOV5Ebolavirus;MB5methyleneRESUL
6、TS:UVCreducedEBOV(4.5log)andMERS-blue;MB/light5methyleneblueincombinationwithCoV(3.7log)infectivityinPCstothelimitofdetection,visiblelight;MERS-CoV5MiddleEastrespiratorysyndromeandMB/lightdecreasedEBOV(4.6log)andMERS-coronavirus;PC(s)5plateletconcentrate(s);PI5pathogenCoV(3.3log)titer
7、sinplasmatonondetectablelevels.inactivation;RF5reductionfactor;TCID50550%tissueCONCLUSIONS:BothTHERAFLEXUV-Plateletscultureinfectiousdose.(UVC)andTHERAFLEXMB-Plasma(MB/light)1effectivelyreduceEBOVandMERS-CoVinfectivityinFromtheInstituteforVirology,PhilippsUniversity
