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1、ACTAOPHTHALMOLOGICASCANDINAVICA1996-ViscouscarbomereyedropsinpatientswithdryeyesEfficacyandsafety.Arandomized,open,cross-over,multicentrestudyKirstenMarnerI,PoulMartinMdler2,MichaelDillon3andEvaRask-Pedersen4VesterVoldgade',Copenhagen;Slotsgade',Hillemd,Denmark;LeoLaboratori
2、esLtd.',Dublin,Ireland;LeoPharmaceuticalProducts4,Copenhagen,DenmarkABSTRACT.Theefficacyandsafetyofanewcarbomercontainingocu-thoseofpolyvinylalcoholcontaininglargelwascomparedtoacommonlyused1.4%polyvinylalcohol-basedartificialtearsinpatientswithdryeyes(PVA)artificialtearprep
3、aration.Sixty-onepatientswithsymptomsandandinnormalsubjects.Inbothpa-signsofdryeyesweretreatedwitheachpreparationseparatelyfortwotientsandsubjectstheaveragecornealcontacttimeandthebreak-uptimeweeksinamulticentre,randomized,opencross-overstudy.Astatisti-weresignificantlylonge
4、rwiththevi-callysignificantdifferenceinfavourofthenewviscouscarbomereyescouseyedropscontainingcarbomerdropscomparedtothePVApreparationwasachievedinreducingthe(Al-Mansouri8(Tabarra1992).symptomof'dryness',thetotalsymptomscoreandinprolongingtheThisstudywasdesignedtoelucidatebr
5、eak-uptime.Duringthecarbomereyedropsperiodthemeandailyfre-theefficacyandsafetyofLubrithal'inquencyofapplicationwas3.92comparedto4.64forthePVAeyedropspatientswithdryeyeswhencomparedperiod(p=0.02).Twenty-threepatients(38%)reportedadverseeventstoa1.4%polyvinylalcohol(PVA)con-on
6、lywhileusingthecarbomergeland5(8%)onlywhileusingthePVAtainingpreparation(Lacril'/Liqui-eyedrops(p<0.001).'Blurredvision'wasthemostcommonadversefilmaAllergan).eventreported.Thepresentcarbomercontainingoculargelmayofferadvantagesinthetreatmentofdryeyes.PatientsandMethodsKegwor
7、ds:artificialtears-carbomergel-dryeyes-polyvinylalcohol-tearbreak-uptime.Arandomized,open,cross-overstudyinvolving7ophthalmologypracticesinActaOphthalrnol.Scand.1996:74:249-252Denmarkwascarriedout.Patientsre-cruitedtothestudyhadtohaveoneorseveralofthefollowingsymptomsofconsi
8、derablepartofophthalmo-Lubrithal'(LeoPharmaceuticaldryeyes:Dryness,burning,
