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1、昆明醫(yī)科大學(xué)學(xué)報2014,35(9):141~143CN53—1221/RJournalofKunmingMedicalUniversity高通量透析對維持性血液透析患者鈣磷代謝的影響蔡艷,白云霞,張永新,楊才,李萬碧,郭燕(個舊市人民醫(yī)院腎內(nèi)科,云南個舊661000)[摘要]目的探討高通量透析(high—fluxhemodialysis,HFHD)對維掙勝血液透析(maintenancehemodia—lysis,MHD)患者鈣磷代謝的影響.方法選擇自2012年8月至2014年2月在個舊市人民醫(yī)院住院的MHD患者86例,隨機(jī)將患者分為觀察組和對照組,觀察組43例采取HFHD治療;而對照組
2、43例則給予低通量透析(1ow—fluxhemodialysis,LFHD)治療.2組患者均透析6個月.治療前后測量2組患者的血鈣、血磷、甲狀旁腺激素(iPTH)和鈣磷乘積等指標(biāo).結(jié)果2組患者治療前血鈣、血磷、iPTH和鈣磷乘積相比,差異無統(tǒng)計學(xué)意義(P>0.05);治療后,觀察組血鈣、血磷、iPTH和鈣磷乘積分別為(3.2±0.3)mmo1]L、(1.8±0.2)mmo1]L、(156.5±32.8)pg/mL和(32.54-3.6)mf/dL2,對照組為(2.14-0.4)mmol/L、(2.14-0.2)mmol/L、(387.24-74.5)pg/mL和(47.14-4.3)mg2
3、/dL:,2組上述指標(biāo)相比,差異具有統(tǒng)計學(xué)意義(P<0.05).結(jié)論HFHD在MHD患者的透析治療中,能明顯清除血磷和iPTH,提高血鈣水平,進(jìn)而改善患者鈣磷代謝狀態(tài).[關(guān)鍵詞]高通量透析;維持性血液透析;鈣磷代謝[中圖分類號]R692[文獻(xiàn)標(biāo)識碼]A[文章編號]2095-610X(2014)09-0141-03ClinicalStudyontheEffectsofHigh-fluxHemodialysisonCalciumandPhosphorusMetabolisminPatientswithMaintenanceHemodialysisCAIYan,BAIYun—xia,ZHANGY
4、ong-xin,YANGCai,LIWan—bi,GUOYan(Dept.ofNephrology,ThePeople’HospitalofGejiuCity,CejiuYunnan661000,China)[Abstract]ObjectiveToobserveandexploretheeffectsofhigh-fluxhemodialysis(HFHD)oncalciumandphosphorusmetabolisminpatientswithmaintenancehemodialysis(MHD).MethodsEighty-sixpatientswithMHDinourhospi
5、talfromAugust2012toFebruary2014wereselectedandrandomlydividedintotheobservationgroupandthecontrolgroup.43casesintheobservationgroupweretreatedwithHFHD,while43patientsinthecontrolgroupweretreatedwithlow-fluxhemodialysis(LFHD).Allpatientsacceptedhemodialysisfor6months.Calcium,phosphorus,parathyroidh
6、ormone(iPTH)andcalcium-phosphorusproductweremeasuredandcomparedinthetwogroupsbeforeandafterhemodialysis.ResultsThedifferencesofcalcium,phosphorus,iPTHandcalcium-phosphorusproductbetweentwogroupsbeforetreatmentwerenotstatisticallysignificant(P>0.05).Afterhemodialysis,calcium,phosphorus,iPTHandcalci
7、um-phosphorusproductwere(3.2±0.3)mmol/L,(1.8±0.2)mmol/L,(156.5±32.8)pg/mLand(32.5±3.6)mgZ/dL2intheobservationgroup,andwere(2.14-0.4)mmol/L,(2.14-0.2)mmol/L,(387.24-74.5)pg/mLand(47.1±4.3)mg2/dL2inthecontrolgroup,