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《鼠神經(jīng)生長(zhǎng)因子對(duì)急性腦出血患者腫瘤壞死因子-α、血清基質(zhì)金屬蛋白酶-9和超氧化物歧化酶水平的影響.pdf》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在應(yīng)用文檔-天天文庫(kù)。
1、·412·實(shí)用藥物與臨床2014年第17卷第4期PracticalPharmacyAndClinicalRemedies，2014，Vo1．17，No．4鼠神經(jīng)生長(zhǎng)因子對(duì)急性腦出血患者腫瘤壞死因子-0【、血清基質(zhì)金屬蛋白酶-9和超氧化物歧化酶水平的影響項(xiàng)婕，潘小娟[摘要]目的探討鼠神經(jīng)生長(zhǎng)因子(NGF)對(duì)急性腦出血患者腫瘤壞死因子一(TNF—)、血清基質(zhì)金屬蛋白酶一9(MMP-9)和超氧化物歧化酶(SOD)水平的影響。方法選擇急性腦出血患者64例，隨機(jī)分為研究組和對(duì)照組。兩組患者均予以控制血壓、血糖和顱內(nèi)壓，營(yíng)養(yǎng)腦細(xì)胞、止血、給氧及維持酸堿平4
2、g-等治療。研究組在此基礎(chǔ)上加用NGF20g肌肉注射，1次／d，連用2周。觀察并比較兩組患者治療前后TNF—d、MMP一9和SOD水平的變化，并觀察兩組的臨床療效和不良反應(yīng)。結(jié)果治療2周后，兩組患者血清TNF一、MMP一9水平均較治療前明顯下降，血清SOD活性較治療前明顯上升，且研究組下降或上升幅度明顯大于對(duì)照組(P<0．05)；同時(shí)兩組患者神經(jīng)功能缺損評(píng)分均有明顯下降(P<0．05或P<0．01)，且研究組下降幅度較對(duì)照組更明顯(P<0．05)，研究組臨床總有效率明顯高于對(duì)照組(=6．56，P<0．05)。兩組患者治療期間均未出現(xiàn)明顯藥物不良
3、反應(yīng)。結(jié)論NGF治療急性腦出血安全有效，作用機(jī)制與降低血漿炎癥因子水平、減輕血腦屏障破環(huán)和改善氧自由基代謝密切相關(guān)。[關(guān)鍵詞]急性腦出血；鼠神經(jīng)生長(zhǎng)因子；腫瘤壞死因子-；血清基質(zhì)金屬蛋白酶-9；超氧化物歧化酶Influenceofmousenervegrowthfactor(NGF)ontumornecrosisfactor-Ix(TNF-0【)，serummatrixmetalloproteinase-9(MMP-9)andsuperoxidedismutase(SoD)levelsofacuteintracerebralhemorrhage
4、patientsXIANGJie，PANXiao-juan(a．PharmaceuticalPreparationDepartment，b．NeurologyDepartment，ThePeoplesHospitalofSongyangCounty，Zhe—iiang323400，China)[Abstract]ObjectiveTodiscusstheinfluenceofmousenervegrowthfactor(NGF)Oiltumornecrosisfac—tor—d(TNF—oL)，serummatrixmetalloprotein
5、ase-9(MMP-9)andsuperoxidedismutase(SOD)levelsofacuteintrace—rebralhemorrhagepatients．Methods64casesofacuteintracerebralhemorrhagepatientswereselectedanddividedin—tostudygroupandcontrolgroupatrandom．Thepatientsinthetwogroupsweregivenmedicaltreatmentsuchasthecontrolofbloodpres
6、sure，bloodsugarandintracranialpressure，braincellsnutrition，hemostasis，oxygentherapy，main—tainingacid—basebalanceandetc．ThepatientsinstudygroupweregivenNGF(20Ixg)byintramuscularinjectiononcedailyfor2weeksadditionally．ThechangesofTNF一．MMP-9andSODlevelsofpatientsinthetwogroupsw
7、ereob—servedandcomparedbeforeandaftermedicaltreatment，andtheclinicalcurativeeffectandadversedrugreactionswereobserved．ResultsAfter2weeksmedicaltreatment．theTNF—ctandMMP一9levelsofthetwogroupsdeclinedthanthosebeforetreatment，whiletheserumSODactivityroseobviously，andthedeclinin
8、gorrisingrateinstudygroupwasmuchhigherthanthatincontrolgroup(P<0．05)．Meanwh
