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1、·484·JShanxiMedUniv,Jan2014.Vol45No6嗅球容積測定對早期帕金森病的診斷價(jià)值俱西馳,王偉,屈秋民,張明,吳謙,羅國剛,金晨旺,宋文峰(西安交通大學(xué)醫(yī)學(xué)院第一附屬醫(yī)院神經(jīng)內(nèi)科,西安710061;陜西省人民醫(yī)院預(yù)防保健科;西安交通大學(xué)醫(yī)學(xué)院第一附屬醫(yī)院影像科;西安交通大學(xué)醫(yī)學(xué)院流行病學(xué)教研室;通訊作者,E-mail:908371001@qq.tom)摘要:目的研究帕金森病(Parkinson’sdisease,PD)嗅球容積變化,探討嗅球容積測定用于早期PD診斷的可能性。方法帕金森病病例組(PD組)及
2、對照組各18例,測定帕金森病統(tǒng)一評分量表(unifiedParkinson’sdiseaseratingscale,UPDRS)Ⅲ量表,進(jìn)行Hoehn—Yahr分期;兩組均用磁共振(magneticresonanceimaging,MRI)測定嗅球容積,并對結(jié)果進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果PD組嗅球容積明顯小于對照組[(90.9±15.68)mmvs(131.2±24.53)mE,P<0.001];PD組中左側(cè)嗅球容積小于右側(cè)嗅球容積[(41.4±10.05)mmvs(46.5±11.49)mm,P<0.01];正常對照組中兩側(cè)嗅球容積
3、無差異[(65.1±13.02)mmvs(66.3±12.94)mm,P>0.05]。結(jié)論早期帕金森病患者存在嗅球容積縮小,磁共振嗅球容積測定可幫助診斷早期PD。關(guān)鍵詞:帕金森??;Hoehn—Yahr分期;磁共振;嗅球容積中圖分類號:R741.04文獻(xiàn)標(biāo)志碼:A文章編號:1007—6611(2014)06—0484—03DOI:10.13753/j.issn.1007—6611.2014.06.013DiagnosticvalueoftheolfactorybulbvolumemeasurementforParkinson’sd
4、iseaseinearlystageJUXichi,WANGWei“,QuQiumin,ZHANGMing’,wUQian,LUOGuogang,JINChenwang,SONGWenfeng(DepartmentofNeurology,F(xiàn)irstAfiliatedHospital,MedicalSchoolof’anflaotongUniversity,Xi’an710061,China;DepartmentofPreventionandHealthCare,People’sHospitalofShaanxiProvince;
5、DepartmentofImaging,F(xiàn)irstAfiliatedHospital,MedicalSchoolofXi’anJiaotongUniversity;DepartmentofEpidemiology。MedicalSchoolofXi’anJiaotongUniversity;Correspondingauthor,E—mail:908371001@qq.com)Abstract:ORctiveToinvestigatethechangesofolfactorybulbvolumeinpatientswithPar
6、kinson’sdisease(PD),andexploreitspossibilityindiagnosisofPDinearlystage.MethodsEighteenPDpatientsand18normalcontrolswerechoseninthisstudy.UP—DRSIIIscalewasusedtoevaluateHoehn-Yahrclassification.Theolfactorybulbvolumewasmeasuredbymagneticresonanceimaging(MRI),andthere
7、sultswerecomparedbetweentwogroups.ResultsOlfactorybulbvolumeinPDgroupwassignificantlylessthanthatincontrolgroup[(90.9±15.68)mmvs(131.2±24.53)mm,P<0.001].TheolfactorybulbvolumewaslessatleftsidethanthatofrightsideinPDgroup[(41.4±10.05)mmvs(46.5±11.49)mm,P<0.01].Incontr
8、olgroup,therewasnodiferenceinol—factorybulbvolumebetweentwosides[(65.1±13.02)mmvs(66.3±12.94)mm3,P>0.05].ConclusionTheolfactorybulb