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1、腫瘤藥學(xué)2013年12月第3卷第6期Anti—tumorPharmacy,December2013,Vo1.3,No.6——447——回生口服液對(duì)晚期非小細(xì)胞肺癌患者血清IL一6和IL一18的影響賈友超,魏亞寧,申紅強(qiáng),田彥敏,臧愛民(河北大學(xué)附屬醫(yī)院腫瘤內(nèi)科,河北保定,071000;保定市清苑縣人民醫(yī)院放射科;超聲科,河北保定,071100)摘要:目的檢測(cè)回生口服液對(duì)晚期非小細(xì)胞肺癌患者血清IL一6和IL一18水平的影響,探討其抗腫瘤的可能機(jī)制。方法將82例晚期非小細(xì)胞肺癌患者隨機(jī)分為聯(lián)合化療組(NP方案化療+回生口服液,42例)和單純化療組(NP方案,40例),
2、化療2個(gè)周期后評(píng)價(jià)其臨床療效,并用酶聯(lián)免疫法(ELISA)檢測(cè)各組治療前后血清IL一6和IL-18的水平。結(jié)果聯(lián)合化療組總有效率為38.1%(16/42),單純化療組總有效率35.0%(14/40),差異無統(tǒng)計(jì)學(xué)意義(P=0.697)。單純化療組治療前后血清IL一6和IL一18水平無顯著性變化(P=o.623)。與治療前比較,聯(lián)合化療組治療后血清IL一6和IL一18水平明顯升高(P=0.005)。結(jié)論回生口服液輔助治療可提高晚期非小細(xì)胞肺癌患者的血清IL一6和IL一18水平,增強(qiáng)其免疫力。關(guān)鍵詞:回生口服液,IL一6,IL一18,非小細(xì)胞肺癌中圖分類號(hào):R734.2
3、文獻(xiàn)標(biāo)識(shí)碼:A文章編號(hào):2095—1264(2013)06—0447-04doi:10.39690.issn.2095—1264.2013.109EfectsofHui-shengOralLiquidontheExpressionofInterleukin-6andInterleukin-18ofPatientswithAdvancedNon-small-cellLungCancerJ/aYouchao1,WeiYaninga,ShenHongqiang2,TianYanmin3,ZangAimin(DepartmentofComprehensiveMedicalO
4、ntology,HospitalAffiliatedtoHebeiUniversity,Baoding,Hebei,071004China;2DepartmentofRadiologists;3DepartmentofUltrasound,People’sHospitalofQingyuanCounty,Baoding,He—bei,071000,China)Abstract:ObjectiveTodetecttheefectsofHui—shengoralliquidontheexpressionofInterleukin一6andInterleukin一18of
5、patientswithadvancednon—small—celllungcancer(NSCLC)andtOinvestigateitspossibleanti—tumormechanism.MethodsEity—twopatientswithadvancedNSCLCwererecruitedandrandomlydividedintotwogroups:thecombinedchemotherapygroup(NPchemotherapyandhui—shengoralliquid,n=42)andthesinglechemotherapy(onlyNPc
6、hemotherapy,n=40).Theef-fectiverateswereevaluatedaftertwocycles’treatment.TheexpressionofserumIL一6andIL一18weredetectedbytheenzymehnkedimmunoassay(ELISA)beforeandaftertWOcycles’treatment.ResultsThetotalefectiveratewas38.1%(16/42)forthecombinedchemotherapygroup,and35.0%(14/40)forthesingl
7、echemotherapygroup;therewasnosignificantdiference(尸:0.697)betweenthetwogroups.NodiferenceWasfoundintheexpressionofIL——6andIL——18beforeandaftertreatmentinthesinglechemotherapygroup(尸=O.623).WhilecomparedwithbeforetreatmenttheexpressionofbothIL一6andIL一18weresignificantlyup—regulatedaft