腎移植患者他克莫司血藥濃度的影響

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1、·中藥臨床·五酯膠囊對(duì)腎移植患者他克莫司血藥濃度的影響吳雪H，蔡林，石姍平，龔敏1，徐偉佳，孔曉龍。(1．解放軍第l81醫(yī)院藥劑科，廣西桂林541002；2．廣西醫(yī)科大學(xué)藥學(xué)院，南寧530021)中圖分類號(hào)R283．65；R699．2文獻(xiàn)標(biāo)志碼A文章編號(hào)1001．0408(2013)43．4095．03DOI10．6039／j．issn．1001-0408．2013．43．22摘要目的：探討五酯膠囊對(duì)腎移植患者他克莫司(FK506)-~-藥濃度的影響。方法：對(duì)實(shí)施同種異體腎移植并予以FK506為基礎(chǔ)的

2、免疫抑制治療的患者進(jìn)行回顧性分析。采用微粒子酶免疫法(MEIA)監(jiān)測患者服用五酯膠囊前后FK506的血藥濃度，記錄FK506的給藥劑量，觀察腎移植術(shù)后免疫抑制的療效、用藥后的不良反應(yīng)，以及用藥對(duì)腎移植患者血常規(guī)的影響。結(jié)果：五酯膠囊用藥前、后FK506的血藥濃度比較差異有統(tǒng)計(jì)學(xué)意義(P

3、與用藥前比較差異無統(tǒng)計(jì)學(xué)意義。結(jié)論：為防止器官移植后的排斥反應(yīng)，腎移植患者在同時(shí)應(yīng)用FK506和五酯膠囊時(shí)，應(yīng)考慮五酯膠囊對(duì)FK506血藥濃度的影響。關(guān)鍵詞他克莫司；五酯膠囊；血藥濃度；微粒子酶免疫法；腎移植EffectsofWuzhiCapsulesonBloodConcentrationofTacrolimusinRenalTransplantationRecipientswUXue，CAILin，SHIShan—ping，GONGMin，XUWei-jia，KONGXiao—long(1．Dep

4、t．ofPharmacy，No．181HospitalofPLA，GuangxiGuilin541002，China；2．SchoolofPharmaceuticalScience，GuangxiMedicalUniversity，Nanning530021，China)ABSTRACT0BJECTIVE：ToexploretheefectsofWuzhicapsulesonbloodconcentrationoftacrolimus(FK506)inrenaltrans．plantationreci

5、pients．METHODS：TheallograftrenalgraftrecipientswhoweretreatedwithFK506wereanalyzedretrospectively．ThebloodconcentrationsofFK506inthepatientsweremonitoredbyMEIAmethodbeforeandaftermedication．DrugdosageofFK506wasrecordedandtherapeuticemcacyofimmunosuppres

6、sion，ADR，theefectsofmedicationonbloodroutinewereob．se~ed．RESUIS：Therewasstatisticalsignific~ceinbloodconcentrationofFK506beforeandaftermedication(P<0．05)．Thebloodconcentration0fFK506increasedbyover60％afterdosageofWuzhicapsulesdoubled，by87．28％inaverage，a

7、ndthedrugshowedgreatindividualdiferenceingrowthrate．TherewaspositivecorrelationbetweentheincreaseofbloodconcentrationofFK506andthedosageofhicapsules．Noacuterejectreactionandseverehepaticfunctioninjurywasfoundaftermedication：therewasnostatisticalsignific

8、anceinbloodroutinebeforeandaftermedication．CONCLUSIONS：Topreventther~iectionreactionaftertransplantoperation．eriectsofWuzhicapsuleonbloodconcentrationofFK506Shouldbeconsideredwhenrenaltransplanta．tionpatintsreceivedFK506andWrhica