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1、SevereAcuteRespiratorySyndrome(SARS)LydiaHo&RuiYangBISC209ProfessorMaryAllenNovember16,02InitialcasesofSARSappearedinSouthChinaFebruary14,03305cases&5deathsfromanunknownacuterespiratorysyndromeMarch03:NewreportsofoutbreakscameinfromHongKong,Singapore&VietnamNewsyndromewasdesignatedas“severeacute
2、respiratorysyndrome,”orSARSMarch17,03:WHOcalledforglobalcollaborativeresearchonSARSMarch12,03:WHOissuedglobalalertaboutSARSMarch24,03:ScientistsinCDCandHKannouncedisolationofnewcoronavirusfromSARSpatientsDNAsequencingshowsthisvirusisdistinctfromallknownhumanpathogensApril25,03:Nearly3000SARScase
3、shavebeenidentifiedinChinaApril20-25,03:OutbreaksinHanoi,HongKong,China,Singapore&TorontoshowedsignsofpeakingCitycloseddownschools&imposesstrictquarantinemeasuresButtheinvestigationcontinues…BytheendofJune,03:MostcountrieswereremovedfromthelistofareaswithrecentlocaltransmissionofSARS:Singapore,H
4、ongKong,Beijing,Toronto,TaiwanThePathogenbehinditall…SARS-CoVVirusDiscoveryofthenewvirusKochspostulatesDiscoveryofnovelcoronavirusinpatientIsolationofcellcultureReproduciblesymptomincellcultureIdenticalisolatesproduced?NovelcoronavirusisthecauseofSARSCoronaviridaeAfamilyoflarge,enveloped,positiv
5、e-sensesinglestrandedRNAvirusIrregularshapeCharacteristic‘club-shaped’surfaceprojections(~20nm)SARS-CoVGenome71%ofthegenomecodesforpolyproteinsRemainder:codesforstructuralproteinsS(spike):receptorbinding,cellfusion,majorantigenE(envelop):envelop-associatedproteinM(membrane):transmembrane-budding
6、N(nucleocapsid):genome-associatedphosphoproteinSARS-CoVGenomeSARS-CoVLifeCycleS-proteinbindstoreceptor?initiationofinducedendocytosisTranslationofviralRNApolymeraseTranscriptionof(+)RNAintogenomicandsubgenomicmRNAinthecytoplasmNproteinsynthesizedfromfreeribosomeSandMproteinsynthesizedinRERBuddin
7、gfromRERasvirion,excretionfromcellviaGolgiSARSCaseDefinitionClinicalSymptomsHighfeverClinicalHistory10daysbeforeonsetofsymptomsClosecontactwithprobable/suspectedSARSpatientsLivein/traveltoareawithtransmissionofSARSTransmissi
