蓖麻籽脫脂提取物對(duì)小鼠離體子宮平滑肌的影響.pdf

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1、·5O·ChineseJournaIofInformationonTCMMay2014VoI．21No．5蓖麻籽脫脂提取物對(duì)小鼠離體子宮平滑肌的影響蘇雅拉圖’一，陳宇杰，穆莎茉莉，王立異’，馮景濤，黃鳳蘭1．內(nèi)蒙古民族大學(xué)生命科學(xué)學(xué)院，內(nèi)蒙古通遼028000；2．內(nèi)蒙古自治區(qū)高校蓖麻產(chǎn)業(yè)工程研究中心，內(nèi)蒙古通遼028000摘要：目的確定蓖麻籽中除蓖麻油之外還有一種物質(zhì)能夠引起小鼠子宮平滑肌收縮異常，為進(jìn)一步研究提供依據(jù)。方法采用石油醚脫脂法獲得蓖麻籽脫脂提取物，提取物分為4、8、l6、32h4個(gè)時(shí)間組和

2、O．15、O．06、0．02mg／mL3個(gè)劑量組，以小鼠離體子宮平滑肌肌張力和收縮周期為指標(biāo)，觀察提取物存放時(shí)間和濃度對(duì)小鼠離體子宮平滑肌的影響。結(jié)果與對(duì)照組比較，提取物4、8、16h組能顯著增強(qiáng)離體子宮平滑肌肌張力(P

3、

4、actofCastorBeanonSmoothMuscleofIsolatedMouseUterusSUYa-latu一，CHENYu~ie’一，MUSha．moli。，WANGLi．yi，F(xiàn)ENGJing．tao，HUANGFeng．1rdn，．CollegeofL啦SciencesInnerMongoliaUniversityfortheNationalities,Tongliao028000,China：2．InnerMongoliaIndustrialEngineeringResearchCen

5、terofUniversitiesforCastor,Tongliao028000,China)Abstract：ObjectiveTodeterminethatinthecastorbeanbesidescastoroilthereisanothersubstancethatcarlcausetheabnormalcontractionofthesmoothmuscleofthemouseuterus，andconsequentlyprovidethebasisforfurtherresearch．M

6、ethodsThedefattedextractofcastorbeanwasobtainedbypetroleumetherdegreasing，takingthetensionandthecontractioncycleofthesmoothmuscleofisolatedmouseuterineasindices，theeffectofthestoragetimeandconcentrationoftheextractonthesmoothmuscleofisolatedmouseuteruswe

7、reobserved．ResultsComparedwiththecontrolgroup，groupswiththestoragetimeoftheextract4，8，16hcouldsignificantlyenhancethetensionofthesmoothmuscleofisolatedmouseuterus(P<0．05，P<0．01)，4，8，16and32hgroupcouldsignificantlydecreasethecontractioncyclerespectively(P

8、0．05)．0．15，0．06and0．02mg／mLgroupcouldsignificantlydecreasethe