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1、ATubularBioreactorforHighDensityCultivationofMicroorganismsIsaoEndo1,TeruyukiNagamune1,SusumuTachikawa2,HidekiInaba21TheInstituteofPhysicalandChemicalResearch,Wako-shi,Saitama,Japan2SumitomoHeavyIndustries,Ltd.,Hiratuka-shi,Kanagawa,Japan1Introduction.................................................
2、.................22DesignoftheTBR............................................................22.1MembraneModule.........................................................22.2ConstitutionandCharacteristicsoftheTBR...................................33ExperimentalDetails..................................
3、.........................43.1Equipment................................................................43.2Method.................................................................43.2.1TestOrganismandCompositionoftheBasalCultureMedium.............43.2.2ExperimentalConditions...................i.......
4、....................53.2.3MeasuringMethod....................................................64ResultsandDiscussion.............................;.............................64.1ComparisonofBatchCultureExperimentsObtainedwiththeTBRwiththoseoftheJarFermentor................................... 9......
5、..................64.2CultivationofLactobacilluscaseiwithCross-FlowFiltrationataConstantDilutionRate.....................................................................74.3CultivationofL.caseiwithCross-FlowFiltrationbyIncreasingDilutionRate......95Conclusion.........................................
6、..........................106Nomenclature.................................................................l17References....................................................................11Bysimulatingthefunctionsoftheanimalintestine,theauthorshavedevelopedanoveltubularbioreactor(TBR)whichiscapableo
7、fcontainingboththereactionandseparationofproductsinasinglesystem.Thisreactorconsistedofinorganicultrafiltrationmembranemodulesintheprimarypartofthesystem,aheatexchangerandarecyclingpump.Theoperationch
