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1、TOKNOWOURSELVES?THEU.S.DEPARTMENTOFENERGYANDTHEHUMANGENOMEPROJECTJULY1996TOKNOWOURSELVES?THEU.S.DEPARTMENTOFENERGYANDTHEHUMANGENOMEPROJECTJULY1996ContentsFOREWORD.............................................................2THEGENOMEPROJECT—WHYTHEDOE?..............
2、..................4AboldbutlogicalstepINTRODUCINGTHEHUMANGENOME....................................6TherecipeforlifeSomedefinitions..........................................................6Aplanofaction..........................................................8EXP
3、LORINGTHEGENOMICLANDSCAPE.................................10MappingtheterrainTwogiantsteps:Chromosomes16and19.....................................12Gettingdowntodetails:Sequencingthegenome...............................16Shotgunsandtransposons......................
4、...........................20Howgoodisgoodenough?................................................26Sidebar:ToolsoftheTrade..................................................17Sidebar:TheMightyMouse.................................................24BEYONDBIOLOGY.....
5、.................................................27InstrumentationandinformaticsSmallerisbetter—Andotherdevelopments....................................27Dealingwiththedata.....................................................30ETHICAL,LEGAL,ANDSOCIALIMPLICATIONS...
6、........................32AnessentialdimensionofgenomeresearchForewordTTHEENDOFTHEROADinLittlehasbeenrapid,anditisnowgenerallyagreedCottonwoodCanyon,nearSaltthatthisinternationalprojectwillproduceLakeCity,AltaisaplaceofthecompletesequenceofthehumangenomeAnear-mythi
7、crenownamongbytheyear2005.skiers.IntimeitmaywellAndwhatismoreimportant,thevalueassumesimilarstatusamongmolecularoftheprojectalsoappearsbeyonddoubt.geneticists.InDecember1984,aconferenceGenomeresearchisrevolutionizingbiologythere,co-sponsoredbytheU.S.Departmentandbi
8、otechnology,andprovidingavitalofEnergy,ponderedasinglequestion:DoesthrusttotheincreasinglybroadscopeofthemodernDNAresearchofferawayofdetect-biolo