阿倫膦酸鈉治療絕經(jīng)后骨質(zhì)疏松癥的療效觀察

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1、阿倫膦酸鈉治療絕經(jīng)后骨質(zhì)疏松癥的療效觀目的觀察阿倫膦酸鈉對絕經(jīng)后婦女原發(fā)性骨質(zhì)疏松癥的有效性和安全性。方法絕經(jīng)后骨質(zhì)疏松患者130例，將患者完全隨機分成觀察組及對照組，各65例。觀察組每周U服阿倫膦酸鈉70mg和元素鈣(碳酸鈣)及骨化醇；對照組口服元素鈣(碳酸鈣)及骨化醇。療程均為12個月；通過骨密度儀觀察治療前及治療后的骨密度的變化。結(jié)果治療12個月后，觀察組L2?4和股骨頸平均骨密度明品高于治療前和對照組治療后[L2?4:(844±116)mg/cm3t匕(788±76)mg/cm3、(785±64)mg/cm3;股骨頸：(681&plusm

2、n;71)mg/cm3比(644±72)mg/cm3、(662±90)mg/cm3],差異均有統(tǒng)計學(xué)意義(P<0.05或P<0.01)。治療過程中未發(fā)現(xiàn)與藥物有關(guān)的不良反應(yīng)。結(jié)論阿倫膦酸鈉治療絕經(jīng)后骨質(zhì)疏松癥有效且安全。【關(guān)鍵詞】絕經(jīng)后骨質(zhì)疏松癥；阿倫膦酸鈉；骨礦鹽密度REffectsofalendronateonpostmenopausalosteoporosisSUNjing-hua,XUXiao-feng,CHIXiao-fei,WANGJing-liang.Departmentoforthopedics,DalianSecondPeople

3、’sHospital,Daliang116011,ChinaCorrespondingauthor:SUNJing-hua,Email：sunjinghua790108@163.com[Abstract]ObjectiveTodeterminetheefficiencyandsafetyofalendronateonprimaryosteoporosisinpostmenopausalwomen.MethodsOnehundredandthirtycasesofpostmenopausalwomenwithosteoporosiswererandomlydividedinto

4、2group(controlgroupandtreatmentgroup).Allsubjectsintreatmentgroupreceivedalendronate70mgweekly.AIIpatientsreceivedsupplementalcalciumandalfacalcidolorallydailyfor12months.ResultsBonemineraldensityofL2?4andfemurneckintreatmentgroupaftertreatmentfor12monthsweremorethanthosebeforetreatmentandthosein

5、controlgroupaftertreatmentfor12months[L2?4:(844±116)mg/cm3、(788±76)mg/cm3、(785±64)mg/cm3；neckoffemur：(681±71)mg/cm3、(644±72)mg/cm3、(662±90)mg/cm3]andthereweresignificantdifferences(P<0.05orP<0.01).Duringtreatment,drugrelatedadversereactionswereoccur

6、red.ConclusionAlendonateiswelleffectiveandsafeatdosesof70mgweeklyinthetreatmentofprimaryosteoporosisinpostmenopausalwomen.【Keywords】Postmenopausalosteoporosis;Alendronate;Bonemineraldensity阿倫膦酸鈉(ALN)[1]是一種新型、高效的含氨基的二膦酸鹽類骨吸收抑制劑。因其具冇抑制破骨細胞，降低骨轉(zhuǎn)移，增加骨量，降低老年脆性骨折的發(fā)生率等作用，已于1995年被美國食品和藥物管理局(FDA)推薦為預(yù)防及治療原

7、發(fā)性骨質(zhì)疏松癥的臨床用藥。本研究旨在觀察U服阿侖膦酸治療絕經(jīng)后女性骨質(zhì)疏松的療效，入選患者為2010年前經(jīng)骨密度儀檢測的絕經(jīng)后骨質(zhì)疏松患者。1對象與方法1.1對象大連地區(qū)絕經(jīng)后因骨質(zhì)疏松癥而住院的患者130例，患者入院行常規(guī)雙能X線吸收法骨密度儀檢查腰椎骨密度值≤980mg/cm2,胸腰椎X線側(cè)位片無壓縮性骨折，具有骨質(zhì)疏松系列癥狀。患者絕經(jīng)年限均>l年，肝腎功能正常，無心律失常病史等。排除肝、腎、甲狀腺、甲狀旁腺，骨髓