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1、血漿五聚素3及冠心病及冠脈病變嚴(yán)重程度相關(guān)性探究[摘要]目的:探討血漿五聚素3(PTX3)與冠心病發(fā)生、發(fā)展的相關(guān)性,并根據(jù)冠脈造影了解其與冠脈嚴(yán)重程度是否相關(guān)。方法：100例受試者分為正常對(duì)照組20例,穩(wěn)定型心絞痛(SAP)組20例,不穩(wěn)定型心絞痛(UA)組30例,急性心肌梗死(AMI)組30例,冠心病3組患者均行冠脈造影檢查,并分別檢測(cè)各組入院第2天血漿PTX3、甘油三酯(TG)、總膽固醇(TC)、低密度脂蛋白膽固醇(LDL-C)、空腹血糖(FBG)和超敏C反應(yīng)蛋白(hs-CRP)等生化指標(biāo),并進(jìn)行
2、比較。冠心病3組患者按Gensini標(biāo)準(zhǔn)對(duì)冠狀動(dòng)脈病變程度進(jìn)行積分,了解PTX3水平是否與冠狀動(dòng)脈嚴(yán)重程度相關(guān)。結(jié)果：SAP組與正常對(duì)照組之間PTX3水平差異無(wú)統(tǒng)計(jì)學(xué)意義(P>0.05),UA組和AMI組PTX3水平高于SAP組和正常對(duì)照組(P0.05)。經(jīng)Spearman相關(guān)分析表明,冠狀動(dòng)脈病變嚴(yán)重程度與PTX3水平無(wú)明顯相關(guān)性,而血漿脂質(zhì)成分指標(biāo)與冠脈病變程度的相關(guān)性似乎更加密切。結(jié)論：PTX3水平與冠心病臨床分型的輕重程度有相關(guān)性,而與冠狀動(dòng)脈嚴(yán)重程度無(wú)明顯相關(guān)性。［關(guān)鍵詞］血漿五聚素3；冠心病
3、；冠狀動(dòng)脈造影［中圖分類號(hào)］R541.4［文獻(xiàn)標(biāo)識(shí)碼］A［文章編號(hào)］1671-7256(2011)02-0134-0512doi：10.3969/j.issn.1671-7256.2011．02.004Studyontherelationshipbetweentheplasmapentraxin3andcoronaryarterydiseases,andtheseverityofcoronaryarterylesionsWANGQiang，SUNJian-hui，WANGMeng-fei，DAIGui-
4、jun（DepartmentofCardiovascular,theThirdAffiliatedHospitalofSuzhouUniversity,Changzhou213003,China)［Abstract］Objective:Toevaluatethecorrelationbetweenpentraxin3levelsandtheoccurrence,evolutionofcoronaryarterydiseases,andexploretherelationshipbetweenpentra
5、xin3levelsandcoronaryarterylesionaccordingtoangiography.Methods:100subjectsweredividedintonormalgroup(n=20),SAPgroup(n=20),UAgroup(n=30)andAMIgroup(n=30).Thethreegroupsofcoronaryarterydiseaseunderwentangiography.Thepentraxin3levelsofeachgroupaswellasTG,T
6、C,LDL-C,hs-CRPandFBGweredetectedontheseconddayofadmission.AccordingtoGensinistandard,criteria12pointswerecalculatedtothethreegroupsofcoronaryarterydiseaseswerecalculatedtounderstandwhetherthePTX3levelscorrelatedwiththeseverityofcoronaryarterylesions.Resu
7、lt:ThedifferentPTX3levelsbetweentheSAPgroupandnormalgroupwerenotstatisticallysignificant(P>0.05).ThePTX3levelsinUAPgroupandAMIgroupweresignificantlyhigherthanthoseoftheothertwogroups(P0.05).Thespearmancorrelationanalysisshowedthattherewasnotasignificantc
8、orrelationbetweenPTX3levelsandtheseverityofcoronaryarterylesions.Buttheplasmalipidandthecoronaryarterylesionappearedtobemorecloselyrelated.Conclusion:ThePTX3levelswerecorrelatedwithseverityofclinicalclassificationincoronar
