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1、Th1B.005ANOVELDEVICEFORPARTICLEBATCHSEPARATIONBASEDONDIELECTROPHORESIS*L.ZhangandA.BosscheDelftUniversityofTechnology,Delft,theNetherlandsABSTRACTdielectrophoresiswhichcandobatchseparationasgoodasInthiswork,anoveldeviceforbatchseparationofCE,butdoesnotsufferfromthecurvesanddoe
2、snotparticlesbasedondielectrophoresis(DEP)ispresented.requiresuchhighseparationvoltagesasCEdoes.Thecurvedpartsofserpentinemicro-channelthatcausesperformancedeteriorationincapillaryelectrophoresis(CE)THEDESIGNduetotheplugdispersionareeffectivelyusedinourTheprincipleschematicoft
3、hedesignisillustratedindesignfordielectrophoreticseparation.Thetop-and-Figure1.Thepressuredifferenceontheseparationbottomfocusingelectrodesareemployedinthechannelgovernsaparabolicflowprofileanddrivestheintermediatestraightsegmentstobringalltheparticlestosamplemixtureforwardalo
4、ngthechannel.TheACthesameenteringpointforthenextcurve.Thedevicewasvoltagesappliedoverthecurvesgeneratehighnon-successfullyfabricatedbybondingtwoprocesseduniformelectricfieldsinthecurves.ForthenegativeDEPsubstrateswithanSU-8layersandwichedinbetween.Theparticles,theDEPforceactsa
5、longtheradiusofthecurvesexperimentalresultwehaveachievedthusfarisingoodtotheoutside.Thelargerparticleswillbedrivenmoretoagreementwiththenumericalsimulationresult.theoutsideofthecurves.SincetheflowvelocityinagivenhorizontalplaneofthecurvedecreasesmonotonouslyKEYWORDSfromthechan
6、nelcentertotheouterchannelwall,theMicrofluidics,Separation,Dielectrophoresislargerparticlesfollowingtheouterpathwillbeleftbehind.Becausethecurvesarebendedintheoppositedirections,INTRODUCTIONtheseparationwillbecancelledtoagreatextend.ModernparticleseparationtechniqueshavebeenTh
7、erefore,thetop-and-bottomfocusingelectrodesareusedfundamentaltomanyadvancesincellbiology,molecularinthestraightsegmentstobringalltheparticlestothegenetics,biotechnologicalproduction,clinicaldiagnostics,channelcenterbeforeenteringthenextcurve.Afteraandtherapeutics[1].Anumberofm
8、ethodshavebeennumberofiterativecurves,particleswillgetfullyde
