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1、ArchivesofVirologyArchivesofVirology66,157--159(1980)?bySpringer-Verlag1980SerologicalRelationBetweenCalfDiarrheaCoronavirusandHema.qglutinatingEneephalomyelitisVirusBriefReportByK.SATO1,Y.I~ffABA1,andM.MATUMOTO21NationalInstituteofAnimalHealth,Tsukuba,Ibaraki,Japa
2、nKitas~toInstitute,Minato-ku,Tokyo,JapanAcceptedMay7,1980SummaryNeutralizing(NT)andhcmagglutination-inhibiting(HI)antibodiestocalfdiarrhea,coronavirus(CDCV)andhemagglutinatingencephalomyelitisvirusofswine(HEV)(strain67N)weredetectedinhighproportionsofnormaladultcat
3、tleandpigsinJapan.SincecomparisonofNTandHItitersintheserumsamplessuggestedanantigenicdifferencebetweentheviruses,crossNTandHItestsoftheseviruseswerecarriedoutwithautiseraraisedinrabbits.ThehomologousNTtitersweremarkedlyhigherthantheheterologoustiters.InHItestsessen
4、tiallythesameresultswereobtained.Thesefindingsindicatethepresenceofamarkeddifferenceinantigenicmake-upbetweenCDCVandHEV.NTandHItestscanclearlydifferentiatetheviruses,Mthoughthereissomecrossreaction.$Coronaviruseshavebeenreportedtobedividedintotwoserologicalgroupsby
5、theaidofthefluorescentantibodytechnique(4).Calfdiarrheacoronavirus(CDCV)andhemagglutinatingencephalomyelitisvirus(HEV)67Nofswinewereclassifiedinonegroup,togetherwithmousehepatitisvirustype3andhumancoronavirus0C43.Theothergroupcomprizedfelineinfectionsperitonitisvir
6、us,transmissiblegastroenteritisvirusofswine,caninecoronavirusandhumancorona-virus229E.Virusesineachgroupwereantigenicallyrelatedtoeachothertovaryingdegrees,butwereantigenieallyunrelatedtoeoronavirusesofthesecondgroup.DuringthestudiesonCDCVandHEVwehappenedtotestsome
7、normalbovineandswineseraforneutralizing(NT)andhcmagglutination-inhibiting(HI)anti-bodiestothesevirusesandobtaineddatasuggestiveofamarkedantigenicdiffer-encebetweentheviruses.AccordinglyweconductedadirectcomparisonbetweenthevirusesbyNTandHItestsusingantiseraraisedin
8、rabbits.11aArch.Virol.66]20304-8608/80/0066/0157/$01.00]58K.SAT0,Y.INABA,andM.MATUSIOTO:CDCVpassagedinbovineembryonickidneycells(2)waskindlysuppl
