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《微電極針道制圖在丘腦底核電刺激治療帕金森病手術(shù)中的應用》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在教育資源-天天文庫。
1、微電極針道制圖在丘腦底核電刺激治療帕金森病手術(shù)中的應用作者：王學廉，高國棟，賀世明，李維新，王舉磊，管定國，陳玲【關(guān)鍵詞】微電極ApplicationofmicroelectrodemappinginsurgeryofdeepbrainstimulationofsubthalamicnucleusinamelioratingthesymptomsofParkinsonsdisease【Abstract】AIM:Toimprovetheprecisionoftargetinginsurgeryofthedeepbrai
2、nstimulationofsubthalamicnucleustoamelioratethesymptomsofParkinsonsdiseasebyrecordingneurophysiologicalcharacteristicsofencounteredcellsalongmicroelectrodetrajectoriesandmappingmotorandnonmotorterritoryofSTNusingmicroelectroderecordingtechniques.METHODS:FromNov
3、ember1999toApril2017,30patientswithParkinsonsdiseaseunderwentthesurgeryofdeepbrainstimulationand45electrodeswereimplantedintotheSTN.IndirectedspiralCTscan12/12imagingbasedanatomictargetingwasused.Microelectroderecordingmappingtechniqueswereemployedandthecellula
4、ractivitywasanalyzedforvariousneurophysiologcalparameters,includingfiringpatterns,firingrate,interspikeintervals,backgroundnoise,evokedpotentialandreactionstomicrostimulation.ImagingsofCT/MRIpreoperativeandSchaltenbrandandWahrenatlaswereoverlapped,soastoidentif
5、ythemotorandnonmotorterritoryofSTNandlineouttheboundarywithadjacentnucleus.Thus,thefunctionaltargetingofSTNandtheoptimalplaceofelectrodeimplantwerepreciselylocated.RESULTS:Onehundredandthirtyonemicroelectroderecordingtrajectoriesandmappingswereaccomplished.Thea
6、veragemicroelectroderecordingtimeforeachtrajectorywas20min,withameanof291trajectories/electrode.RecordingsfromtheSTNexhibitedanincreaseinthebackgroundactivityandanirregularfiringpattern,withameanrateofHz.Themeancelldensitywascells/mm,withanaveragelengthfromuppe
7、rboundertolower12/12bounderofmm.ThemovementrelatedcellswerelocatedprimarilyinthedorsolateralsectoroftheSTN,withthelegarealocatedmedialalongthemediolateralaxisandcentrallyalongtheanteroposterioraxis,comparedwiththearmarea.Tremorsynchronizedcellscanalsoberecorded
8、andidentified.Thetargetchangeratewas89%.CONCLUSION:ApplicationofmicroelectroderecordingmappingtechniquescanpreciselylocatethemotorandnonmotorterritoryofSTNandlineoutthebound
