泌尿內(nèi)科醫(yī)學(xué)論文范文

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1、慢性腎功能不全患者血栓調(diào)節(jié)蛋白與心腦血管并發(fā)癥關(guān)系的探討　　作者：李忠心，陳向東作者單位：100020北京，首都醫(yī)科大學(xué)附屬北京朝陽(yáng)醫(yī)院腎內(nèi)科　　【摘要】目的探討慢性腎功能不全患者血栓調(diào)節(jié)蛋白(Tm)與心腦血管并發(fā)癥的關(guān)系。方法北京朝陽(yáng)醫(yī)院腎內(nèi)科2005～2006年期間住院的86例慢性腎臟病患者，按照CKD分期標(biāo)準(zhǔn)劃分為腎功能正常組(GFR≥90ml/min)42例和腎功能不全組(GFR<89ml/min)44例。合并心、腦血管疾病的診斷均根據(jù)其臨床表現(xiàn)、生化指標(biāo)和冠脈造影或CT、MRI等影像學(xué)改變。清晨空腹采靜脈血分別測(cè)定血肌酐、膽固醇、甘油三酯、高密度脂蛋白、低密度脂

2、蛋白及血栓調(diào)節(jié)蛋白。結(jié)果慢性腎臟病腎功能不全組Tm水平明顯高于腎功能正常組和對(duì)照組(P<005)，伴心腦血管并發(fā)癥患者Tm水平較不伴并發(fā)癥患者明顯升高(P<005)。將86例患者作為一個(gè)整體，進(jìn)行多元逐步回歸分析，結(jié)果顯示：血栓調(diào)節(jié)蛋白、低密度脂蛋白、收縮壓和血肌酐分別與慢性腎臟病合并心腦血管并發(fā)癥密切相關(guān)。結(jié)論慢性腎臟病功能不全患者血栓調(diào)節(jié)蛋白升高，血栓調(diào)節(jié)蛋白與慢性腎臟病合并心腦血管并發(fā)癥密切相關(guān)。　　【關(guān)鍵詞】慢性腎臟病;慢性腎功能不全;血栓調(diào)節(jié)蛋白　　Relationshipbetweenthrombomodulinandcardio-cerebrovascu

3、larcomplicationsinpatientswithchronicrenalfailure　　LIZhong-xin，CHENXiang-dong.DepartmentofNephrology，ChaoyangHospitalofCapitalMedicalUniversity，Beijing100020，China　　[Abstract]ObjectiveTodeterminetherelationshipbetweenthrombomodulinandcardio-cerebrovascularcomplicationsinpatientswithchroni

4、crenalfailure.MethodsEighty-sixchronickidneydiseases(CKD)patientsfromDepartmentofNephrology，ChaoyangHospital.and60healthyvolunteerswereincludedinthisstudy.Eighty-sixCKDpatientsweredividedintorenalfailuregroupandnormalrenalfunctiongroupaccrodingtoCKDstagingstandard.Diagnosisofcardio-cerebr

5、ovascularcomplicationswasonthebasisofclinicalmanifestation，biochemicalindicator，coronaryarteringraphy，CT，MRI，etal.Bloodwasdrawnafteranovernightfast.BloodlevelsofthrombomodulinweremeasuredusingELISAmethod.Therewerealsobloodtesttomeasurecreatinine(Scr)，triglycerides(TG)，cholesterol(ChoL)，lo

6、w-densitylipoproteincholesterol(LDL)，high-densitylipoproteincholesterol(HDL).ResultsThemeanlevelofTmwashigherinchronicrenalfailurepatientsthanthatinnormalrenalfunctionpatientsandinthehealthycontrols(P<005).ThemeanlevelofTmwassignificantlyhigherinchronicrenalfailurepatientswithcardio-cere

7、brovascularcomplicationsthanthatinpatientswithoutcardio-cerebrovascularcomplications(P<005).MultivariatestepwiseregressionanalysisshowedthatinCRFpatients，thecorrelationassociatedwithcardio-cerebrovascularcomplicationswereTm，LDL，SBP，Scr.ConclusionSerumthrombomodulin