經(jīng)肝動脈熱化療栓塞在晚期肝癌治療中的臨床應(yīng)用

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1、經(jīng)肝動脈熱化療栓塞在晚期肝癌治療中的臨床應(yīng)用【摘要】目的：探討經(jīng)肝動脈熱化療栓塞在晚期肝癌治療中的臨床應(yīng)用價(jià)值。方法：選取2011年1月-2013年11月本院收治的原發(fā)性肝癌晚期患者92例作為研宄對象，依據(jù)隨機(jī)分配原則分為熱化療栓塞組和對照組，每組46例。對照組患者給予常規(guī)經(jīng)肝動脈化療栓塞治療，熱化療栓塞組患者給予經(jīng)肝動脈熱化療栓塞治療（藥物及腆油加熱到60°C），檢測分析所有患者治療前后外周血中丙氨酸氨基轉(zhuǎn)移酶（ALT）、天冬氨酸氨基轉(zhuǎn)移酶（AST）及總膽紅素（TBIL）水平變化；隨訪24個(gè)月，統(tǒng)計(jì)分析所有患者有效

2、率和6、12、18、24個(gè)月的生存率。結(jié)果：熱化療栓塞組有效率為80.43%,明顯高于對照組的58.70%,比較差異有統(tǒng)計(jì)學(xué)意義（P0.05）。結(jié)論：經(jīng)肝動脈熱化療栓塞治療可有效提高晚期肝癌患者的療效，有利于延長患者的生存時(shí)間，值得臨床進(jìn)一步推【關(guān)鍵詞】經(jīng)肝動脈熱化療栓塞；化療栓塞；晚期肝癌；生存率ClinicalApplicationofThermochemoembolizationViaHepaticArteryintheTreatmentofAdvancedLiverCancer/CHENGYu,ZHANGSh

3、eng，RAOXiao-hui,etal.//MedicalInnovationofChina，2016,13(22)：051-055【Abstract】Objective:Todiscusstheapplicationvalueofthermochemoembolizationviahepaticarteryinthetreatmentofadvancedlivercancer.Method：FromJanuary2011toNovember2013，92casesofadvancedlivercancerinou

4、rhospitalwereselectedastheresearchobjects，theyweredividedintothethermochemoembolizationgroupandcontrolgroupaccordingtotheprincipleofrandomdistribution,eachgrouphad46cases.Thecontrolgroupreceivedstandardchemoembolizationtherapyviahepaticartery,andthermochemoembo

5、lizationgroupreceivedchemoembolizationwithdrugsheatedto60°Cviahepaticartery.Beforeandafterthetreatment，thelevelsofserumalanineaminotransferase(ALT),aspartateaminotransferase(AST)andtotalbilirubin(TBIL)weredetectedandanalyzed.Allpatientswerefollowedupfor24months

6、,effectiveremissionrateandsurvivalrateof6,12，18，24monthswerestatisticalanalyzed.Result：Thermochemoembolizationgroupeffectiveremissionratewas80.43%,significantlyhigherthan58.70%ofthecontrolgroup，thedifferenceswasstatisticallysignificant(P0.05).Conclusions：Thermo

7、chemoembolizationviahepaticarterycaneffectivelyimprovethecurativeeffectofpatientswithadvancedlivercancer，andisbeneficialtoextendthesurvivaltimeofthesepatients，itisworthoffurtherclinicalpromotion.【Keywords】Thermochemoembolization；Chemoembolization；Advancedliverc

8、ancer；SurvivalrateFirst-author’saddress：CentralPeople'sHospitalofHuizhouCity，Huizhou516001，China2.3兩組患者治療前后外周血中ALT、AST及TBIL水平比較兩組患者治療前外周血中ALT、AST及TBIL水平比較差異均無統(tǒng)計(jì)學(xué)意義(P>0.05)；治