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《藥學(xué)畢業(yè)論文納米珍珠粉對(duì)大鼠深ⅱ°燒傷創(chuàng)面愈合的影響》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、XX大學(xué)畢業(yè)論文納米珍珠粉對(duì)大鼠深I(lǐng)I°燒傷創(chuàng)面愈合的影響2014年6月25日作者：崔淑芳，郝光榮，湯球，孫偉，曹平【摘要】目的研究納米珍珠粉對(duì)大鼠深I(lǐng)I。燒傷創(chuàng)面愈合的影響并與微米珍珠粉在燒傷愈合中進(jìn)行藥效比較。方法納米珍珠粉、微米珍珠粉(0.5g/只)分別與甘油按1:1配制成混合液。以微米珍珠粉組與自然愈合組作對(duì)照，納米珍珠粉組為實(shí)驗(yàn)組。測(cè)定大鼠14%深I(lǐng)I。燙傷后7、15、21天的創(chuàng)面愈合率、創(chuàng)面組織學(xué)觀察以及皮膚疑脯氨酸的含量。結(jié)果納米珍珠粉組創(chuàng)而愈合率較微米珍珠粉組、自然愈合組高(P<0.05或PV0.01
2、)；燒傷后3天各組皮膚耗脯氨酸含量均低于正常(PV0.01),納米珍珠粉組減少程度小于其他組；傷后5天各組HP含量有所恢復(fù)，尤以納米珍珠粉組顯著高于自然愈合組及微米珍珠粉組；10天后各組明顯升高，而納米珍珠粉組HP含量的升高差界有非常顯著性(PV0.01)。結(jié)論納米珍珠粉可以促進(jìn)大鼠深I(lǐng)I。燒傷創(chuàng)而的愈合，其愈合作用明顯高于微米珍珠粉(P<0.05)o【關(guān)鍵詞】納米珍珠粉；微米珍珠粉；燒傷；羥脯氨酸[Abstract]ObjectiveTostudytheefficiencycomparisonbetweennano
3、andmicropearlpowderfortreatmentofdeepII°skinscaldsinrats.MethodsNanoandmicropearlpowder(0.5geachrat)aremixedwithglycerol(1:l).Withthemicropearlpowdergroupandthenonnalhealinggroupasthecontrol,nanopearlpowderwereusedasdrugonthedeepII°skinscaldsofratsintheexperime
4、ntalgroups.Woundhealingrateswasmeasuredat7,15,21dayspost-injury；andthecontentofhydroxyproline(HP)weredetectedalso.ResultsWoundhealingratesofthenanopearlpowdergroupwerehigherthanthatofthemicropearlpowdergroupandthenormalhealinggroup(P<0.05orP<0.01).Atthe3thdaypo
5、st-injury,thecontentofHPineverygroupwerelowerthanthatinthenormalgroup(P<0.01),whilethedecreaseinthenanopearlpowdergroupwasslightthanthoseinothergroups.Atthe5thdaypost-injury,thecontentofOHPrecoveredtosomeextent,withasignificantlyhigherelevationinthenanopearlpow
6、dergroupthanthoseinothergroups.Atthe10thdaypost-injury,evidentHPincreasewasfoundineverygroup,withastatisticalsignificanthigherelevationinthenanopearlpowdergroup(P<0.01).ConclusionNanopearlpowdercouldpromotethewoundhealingofdeepII°skinscaldsinratssignificantly,i
7、t'shealingwasmorehigherthanthatofmicronpearlpowde匚【Keywords】nanopearlpowder；micropearlpowder；scald；hydroxyproline(HP)Thisresearchistostudythewoundhealingefficacyofnanopearlpowderintreatmentofdeep11°skinscaldsinratsandcomparethefunctionwiththoseofmicronpearlpowd
8、er.1Materialandmethods1.1Pearlpowder(ZhejiangFenixPharmaceuticalCo,Ltd),nanoandmicropearlpowder(0.5geachrat)aremixedwithglycerol(1:1).Dermalhydroxyprolincdetectionkit(Nanjin
