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1、生物化工專業(yè)翻譯1.AbstractAmyloiddisorderscausedebilitatingillnessesthroughtheformationoftoxicproteinaggregates.Themechanismsofamyloidtoxicityandthenatureofspeciesresponsibleformediatingcellulardysfunctionremainunclear.Here,usingp2-microglobulin(
2、32m)asamodelsystem,weshowthatthedisruptiono
3、fmembranesbyamyloidfibrilsiscausedbythemolecularsheddingofmembrane?activeoligomersinaprocessthatisdependentonpH.UsingthioflavinT(ThT)fluorescenee,NMR,EMandfluoresceneecorrelationspectroscopy(FCS),weshowthatfibrildisassemblyatpH6.4resultsintheformationofnormativesphericaloligomersth
4、atdisruptsyntheticmembranes.Bycontrast,fibrildissociationatpH7.4resultsintheformationofnontoxic,nativemonomers?Chemicalcross-linkingorinteractionwithhsp70increasesthekineticstabilityoffibrilsanddecreasestheircapacitytocausemembranedisruptionandcellulardysfunction.Theresultsdemonstr
5、atehowpHcanmodulatethedeleteriouseffectsofpreformedamyloidaggregatesandsuggestwhyendocytictraffickingthroughacidiccompartmentsmaybeakeyfactorinamyloiddisease.抽象淀粉樣蛋白疾病引起通過(guò)毒性蛋白聚集體的形成衰弱的疾病。淀粉樣蛋白的毒性的機(jī)制，負(fù)責(zé)調(diào)解細(xì)胞功能障礙品種的性質(zhì)仍然不清楚。在這里，用B2微球蛋白(P2M),其為模型系統(tǒng)，我們表明，膜的由淀粉樣蛋白原纖維的破壞是通過(guò)膜-活性低聚物的分子屮脫落的處理
6、是依賴于pH值而引起的。使用硫磺素T(ThT的)熒光,NMREM和熒光相關(guān)光譜(FCS),我們表明，原纖維的拆卸，在pH6.4的結(jié)果屮的非天然寡聚球形擾亂合成膜的形成。相比Z下，原纖維解離，在pH7.4的結(jié)果在無(wú)毒，天然單體的形成。化學(xué)交聯(lián)或相互作用與HSP70增加纖維的動(dòng)力學(xué)穩(wěn)定性，并降低它們的容量以使膜破壞和細(xì)胞功能障礙。結(jié)果表明如何pH值可以調(diào)節(jié)預(yù)形成的淀粉樣蛋白聚集體的有害作用，并說(shuō)明為什么通過(guò)酸性隔室的內(nèi)吞販賣可以是在淀粉樣蛋白病的關(guān)鍵因素。2.AbstractDuringthelastdecade,severalpiecesofconvincin
7、gevideneewerepublishedindicatingthatagingoflivingorganismsisprogrammed,beingaparticularcaseofprogrammeddeathoforganism(phenoptosis).Amongthem,thefollowingobservationscanbementioned[1].Speciesweredescribedthatshownegligibleaging.Inmammals,thenakedmoleratisthemostimpressiveexample?Th
8、isisarodentofmousesizelivingatleast10-foldIongerthanamouseandhavingfecundityhigherthanamouseandnoage-relateddiseases[2].Insomespecieswithhighagingrate,genesresponsibleforactiveorganizationofagingbypoisoningoftheorganismwithendogenousmetaboliteshavebeenidentified[3].Inwomen,standard
9、deviationsdividedbythemean
