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1、生物化工專業(yè)翻譯1.AbstractAmyloiddisorderscausedebilitatingillnessesthroughtheformationoftoxicproteinaggregates.Themechanismsofamyloidtoxicityandthenatureofspeciesresponsibleformediatingcellulardysfunctionremainunclear.Here,usingβ2-microglobulin(β2m)asamodelsys
2、tem,weshowthatthedisruptionofmembranesbyamyloidfibrilsiscausedbythemolecularsheddingofmembrane-activeoligomersinaprocessthatisdependentonpH.UsingthioflavinT(ThT)fluorescence,NMR,EMandfluorescencecorrelationspectroscopy(FCS),weshowthatfibrildisassemblyat
3、pH6.4resultsintheformationofnonnativesphericaloligomersthatdisruptsyntheticmembranes.Bycontrast,fibrildissociationatpH7.4resultsintheformationofnontoxic,nativemonomers.Chemicalcross-linkingorinteractionwithhsp70increasesthekineticstabilityoffibrilsandde
4、creasestheircapacitytocausemembranedisruptionandcellulardysfunction.TheresultsdemonstratehowpHcanmodulatethedeleteriouseffectsofpreformedamyloidaggregatesandsuggestwhyendocytictraffickingthroughacidiccompartmentsmaybeakeyfactorinamyloiddisease.抽象淀粉樣蛋白疾病
5、引起通過毒性蛋白聚集體的形成衰弱的疾病。淀粉樣蛋白的毒性的機(jī)制，負(fù)責(zé)調(diào)解細(xì)胞功能障礙品種的性質(zhì)仍然不清楚。在這里，用β2微球蛋白（β2M），其為模型系統(tǒng)，我們表明，膜的由淀粉樣蛋白原纖維的破壞是通過膜-活性低聚物的分子中脫落的處理是依賴于pH值而引起的。使用硫磺素T（ThT的）熒光，NMREM和熒光相關(guān)光譜（FCS），我們表明，原纖維的拆卸，在pH6.4的結(jié)果中的非天然寡聚球形擾亂合成膜的形成。相比之下，原纖維解離，在pH7.4的結(jié)果在無毒，天然單體的形成?；瘜W(xué)交聯(lián)或相互作用與HSP70增加纖維的動力
6、學(xué)穩(wěn)定性，并降低它們的容量以使膜破壞和細(xì)胞功能障礙。結(jié)果表明如何pH值可以調(diào)節(jié)預(yù)形成的淀粉樣蛋白聚集體的有害作用，并說明為什么通過酸性隔室的內(nèi)吞販賣可以是在淀粉樣蛋白病的關(guān)鍵因素。2.AbstractDuringthelastdecade,severalpiecesofconvincingevidencewerepublishedindicatingthatagingoflivingorganismsisprogrammed,beingaparticularcaseofprogrammeddeatho
7、forganism(phenoptosis).Amongthem,thefollowingobservationscanbementioned[1].Speciesweredescribedthatshownegligibleaging.Inmammals,thenakedmoleratisthemostimpressiveexample.Thisisarodentofmousesizelivingatleast10-foldlongerthanamouseandhavingfecundityhigh
8、erthanamouseandnoage-relateddiseases[2].Insomespecieswithhighagingrate,genesresponsibleforactiveorganizationofagingbypoisoningoftheorganismwithendogenousmetaboliteshavebeenidentified[3].Inwomen,standarddeviationsdividedbythemeana
