下頜前移矯治對(duì)osahs兔血漿no肺小動(dòng)脈的影響

《下頜前移矯治對(duì)osahs兔血漿no肺小動(dòng)脈的影響》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。

1、中文摘要與對(duì)照組相比變化并不明顯；對(duì)照組中膜很薄。6．2肺微動(dòng)脈(d弋<409m)的組織學(xué)觀察：HE染色較難辨別三組間差別。EVG彈力纖維染色鏡下觀察發(fā)現(xiàn)OSAHS組出現(xiàn)較多的肌性動(dòng)脈，即肺微動(dòng)脈有內(nèi)外兩層彈力膜，其間有平滑肌細(xì)胞環(huán)繞；MAD組大部分肺微動(dòng)脈僅有一層彈力膜包繞，類似于對(duì)照組。。7肌性肺動(dòng)脈相對(duì)中膜厚度的測定：OSAHS組、MAD組及對(duì)照組的WT％分別為13．07±O．56％、9．05±0．36％、8．62±0．46％。OSAHS組Ⅵ嚇％顯著高于MAD組及對(duì)照組，有統(tǒng)計(jì)學(xué)差異(PO．05)。8肺

2、微動(dòng)脈百分比的測定：OSAHS組、MAD組及對(duì)照組肌性動(dòng)脈和部分肌性動(dòng)脈占肺微動(dòng)脈的百分比分別為22．56％、8．75％、7．64％。OSAHS組明顯高于MAD組及對(duì)照組，有統(tǒng)計(jì)學(xué)差異(PO．05)。結(jié)論：OSAHS可引起兔血漿NO及肺小動(dòng)脈結(jié)構(gòu)的改變，MAD對(duì)OSAHS引起的肺血管結(jié)構(gòu)改變具有預(yù)防作用。關(guān)鍵詞：阻塞性睡眠呼吸暫停低通氣綜合征；動(dòng)物模型；下頜前移矯治器；一氧化氮；肺小動(dòng)脈k～英文摘要EffectsofMADonNOinPlasmaandSmallPulmonaryArteriesofOSAHSRabbitsA

3、BSTRACTobjective：Throughtheanimalmodelofobstructivesleepapnea-hypopneasyndrome(OSAHS)established，theeffectsofOSAHSandtreatmentofmandibularadvancementdevice(MAD)onnitricoxied(NO)inplasmaandsmallpulmonaryvesselswereobserved．ThisexperimentprovidedtheoreticaltestbasisforclinicalusingMADtotreat

4、OSAHSandtopreventdamagesofthesmallpulmonaryarteries．Method：ThirtymaleNewZealandrabbitsweredividedintothreegroupsatrandom：groupOSAHS，groupMADandcontrolgroup．1％sodiumpentobarbitalwasinjectedintogroupOSAHSandMAD．Onetotwomillilitersmixedcolloidwasinjectedintomuscularismucosaofsoftpalatewhichwa

5、s0．5centimetertotheboundaryofsoftandhardpalate．Thegelwasstoppedinjectinguntilthesubjectsshowedobvioussnoringandapnea．Thecephalometricaldataofsupinepositionshowedtheupperairwaywidthof1／4point，middlepointand3／4pointofsoftpalateweresignificantlydecreasedcomparedwithcontrolgroup．Bloodgasanalys

6、isshowedthatbloodoxygensaturationdecreasedby22％aftermodelestablished．Thosedemonstratedthatanimalmodelhadbeenestablishedsuccessfully．ThengroupMADwerewornmandibularadvanceddevice．Aftertheanimalmodelestablishedsuccessfully,eachgroupwasgiven10％chloralhydrate(5--6ml／kg)throughoralcavityandslept

7、4--6hoursinasupinepositioneveryday．Onthesecondday,cephalometricaldataandbloodgasanalysisofthreegroupswereconductedagainduringsleep．After8weeks，threegroupsofanimalswereanaesthetizedthewithl％pentobarbitalsodium．TwomillilitersbloodWasdrawnfromtheearveintomakeanal