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《含胺功能單體的乳液共聚物合成研究》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、摘要為了制備具有酸溶性的共聚物乳液，我們選用含胺功能單體甲基丙烯酸二甲氨基乙酯(DMAEMA)，用半連續(xù)乳液聚合方法制備苯乙烯一丙烯酸丁酯一甲基丙烯酸二甲氨基乙酯(St／BA／DMAEMA)Z元共聚物。乳膠加入其他填料可直接用于藥物包衣，簡(jiǎn)化了包衣生產(chǎn)過(guò)程，也克服了使用有機(jī)溶劑帶來(lái)的污染。水溶性單體DMAEMA共聚使得乳液聚合體系較為復(fù)雜，本文系統(tǒng)研究了乳化劑種類和用量、引發(fā)劑用量、聚合溫度、功能單體含量和單體加料方式及加料速率對(duì)聚合體系穩(wěn)定性及轉(zhuǎn)化率的影響。實(shí)驗(yàn)結(jié)果表明DMAEMA存在使得體系穩(wěn)定性、轉(zhuǎn)化率都有所下降，減慢單體的加料速率則有利于聚合穩(wěn)定、轉(zhuǎn)化
2、率提高。實(shí)驗(yàn)結(jié)果還表明，對(duì)于本聚合體系半連續(xù)乳液聚合要優(yōu)于間歇法，種子半連續(xù)聚合法優(yōu)于無(wú)種子半連續(xù)法，而含AA的種子半連續(xù)乳液聚合比含DMAEMA的種子半連續(xù)乳液聚合無(wú)論在聚合穩(wěn)定性、轉(zhuǎn)化率及DMAEMA用量上都有很大的提高。本文還初步研究了在種子聚合過(guò)程中乳膠粒徑的變化，表明加料速率加快、單體中DMAEMA含量增大都使乳膠粒聚并現(xiàn)象明顯，粒徑增大。本文還研究了影響乳液成膜后酸溶性的因素，結(jié)果表明DMAEMA含量增大、共聚物分子量降低都有利于酸溶。關(guān)鍵詞：酸溶性，乳液共聚合，甲基丙烯酸二甲氨基乙酯，藥用包衣材料乳膠粒聚并AbstractDimethylamin
3、oethylmethacrylate(DMAEMA)wasusedtoobtainlatexhavingacid—solublepropertywhichcanbeusedasgastric—solublecoatings．TheterpolymerlatexofStyrene—Butylacrylate—Dimethylaminoethylmethacrylatewaspreparedinbothbatchandsemi．batchemulsioncopolymerizations．TheemulsioncopolymerizationcontainingD
4、MAEMAbecamecomplex．Theeffectsofemulsifiertypeandamount,initiatoramount，copolymerizationtemperature，contentofDMAEMA，thefeedpolicyandfeedrateofcomonomersonthestabilityandconversionofcopolymerizationsystemwerestudiedsystematically．TheresultsshowthatincreaseofcontentoffunctionalmonomerD
5、MAEMAcandecreasestabilityandconversionofcopolymerizationsystem．Areductionofthefeedrateofmonomersisfavorabletotheprocess．Theresultsalsoshowthat，forthissystem，batchcopolymerizationisinferiortosemi—batchcopolymerization，thenonseededemulsioncopolymerizationisinferiortoseededprocess．Theo
6、ptimizationalprocessisseededcopolymerizafionusingasmallamountofAcrylicacid(AA)innucleationperiod．Thegrowthofparticleswasstudiedprimarilyintheseededcopolymerization，theresults-showthatincreaseofthefeedrateofmonomersandincreaseofcontentofDMAEMACanpromotecoagulation，obtaininglargeparti
7、cles．Factorsthatinfluencingtheacid-solubilityofthefilmwerealsostudied．AnincreaseofDMAEMAcontentanddecreaseofthemolecularweightofcopolymerswillfavorthesolutionprocess．Keywords：acid-soluble，emulsioncopolymerization，Dimethylaminoethylmethacrylate，pharmaceuticalcoatingmaterials，particle
8、coagulation獨(dú)創(chuàng)性聲明本人聲
