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1、提要目的：骨痹寧方治療膝骨關(guān)節(jié)炎的臨床觀察。方法：收集60例符合本臨床研究的膝骨關(guān)節(jié)炎患者，隨機(jī)方法分為試驗(yàn)組和對(duì)照組，每組30例。試驗(yàn)組予骨痹寧方，水煎服，日一劑；對(duì)照組予硫酸氨基葡萄糖膠囊，每次2粒，每日3次，3個(gè)月后觀察兩組患者的病情輕重及中醫(yī)證候積分療效和疾病總療效，同時(shí)觀測(cè)實(shí)驗(yàn)室及安全性指標(biāo)，判定臨床療效。骨痹寧方的功效：補(bǔ)益肝腎，舒筋通脈。結(jié)果：試驗(yàn)組和對(duì)照組治療前后的病情輕重差異有統(tǒng)計(jì)學(xué)意義，（p<0.05)說明兩組藥物對(duì)于治療膝骨關(guān)節(jié)炎均有顯著療效。治療后兩組之間的病情差異有統(tǒng)計(jì)學(xué)意義，（p<0.05)說明試驗(yàn)組在改善病情輕重方面優(yōu)于對(duì)照組。治療后試驗(yàn)組臨床
2、痊愈3例，顯效7例，有效18例，無效2例；對(duì)照組臨床痊愈1例，顯效3例，有效20例，無效6例。兩組之間的中醫(yī)證候療效差異有統(tǒng)計(jì)學(xué)意義，（p=0.03<0.05)說明試驗(yàn)組相對(duì)于對(duì)照組，更顯著的改善中醫(yī)證候的療效。治療后試驗(yàn)組臨床控制2例，顯效5例，有效20例，無效3例，總有效率90.0%;對(duì)照組臨床控制1例，顯效1例，有效21例，無效7例，總有效率76.7%。兩組之間疾病總療效差異有統(tǒng)計(jì)學(xué)意義，.(p=0.04<0.05)說明試驗(yàn)組總療效優(yōu)于對(duì)照組。試驗(yàn)組和對(duì)照組治療前后組內(nèi)血沉差異均有統(tǒng)計(jì)學(xué)意義，（p<0.05)說明兩組均能降低血沉。治療后試驗(yàn)組和對(duì)照組血沉比較差異無統(tǒng)計(jì)
3、學(xué)意義（P=0.76〉0.05),說明試驗(yàn)組和對(duì)照組在降低患者血沉方面的療效相當(dāng)。兩組組內(nèi)及組間的安全性觀測(cè)指標(biāo)比較，（p>0.05)差異無統(tǒng)計(jì)學(xué)意義。結(jié)論：骨痹寧方在減輕膝骨關(guān)節(jié)炎患者的疼痛、改善臨床癥狀和體征等方面有較好的療效，同時(shí)注重補(bǔ)益肝腎，達(dá)到了治病求本的目的。因此在正確辨證的基礎(chǔ)上，此方治療膝骨關(guān)節(jié)炎值得推廣。?關(guān)鍵詞膝骨關(guān)節(jié)炎：中醫(yī)藥治療；骨痹寧方；臨床觀察ClinicalobservationoftreatmentofosteoarthritisofthekneeinGubiningfangSpeciality:InternalmedicineofTCM.
4、thestudyofRheumaticimmunediseasesAuthor:GongZhaoweiTutor:ProfessorSunSupingAbstractObjective:ToobservetheGubiningfangratherTreatmentofkneeosteoarthritisclinicalefficacy.Methods:Wardsandoutpatientcollected60casesofthisclinicalstudyinpatientswithosteoarthritisoftheknee,wererandomlydividedint
5、oexperimentalandcontrolgroup,n=30cases.Gubiningfangtestgroupweregivenwaterandaday;Controlgroupweregivenyisuojia,each2,3timesaday,threemonthsaftertheobservationoftheseverityofthetwogroupsofpatientsandTCMsyndromescoreThetotaleffectoftheefficacyanddiseaseobservationlaboratoryandsafetyindicato
6、rstodeterminetheclinicalefficacy.Gubiningfangrathersideeffect:liverandkidneytonic，theShujintongmai.Results:Theseverityofdifferencesintheexperimentalgroupandcontrolgroupwerestatisticallysignificant，(p<0.05)twodrugsforthetreatmentofkneeosteoarthritishaveasignificanteffect.Conditiondifference
7、sbetweenthetwogroupsaftertreatmentwasstatisticallysignificant,(p<0.05)indicatingthattheexperimentalgroupinimprovingseveritythanthecontrolgroup.Clinicaltrialgrouphealedaftertreatment,threecaseswerecured,7cases,18casesofeffectiveandineffectivein2cases;clinicalre
