固本祛瘀,化痰調脂法治療老年高脂血癥的臨床觀察

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1、提要目的：觀察固本祛瘀，化痰調脂法治療老年高脂血癥的臨床療效，并探討其作用機理。方法：采用隨機雙盲分組的方法，將符合納入標準的60例老年高脂血癥患者分為治療組和對照組兩組，每組各30人。治療組采用固本調脂湯加辛伐他汀10mg治療；對照組采用辛伐他汀20mg治療。8周為一個療程。治療前后檢測患者血清總膽固醇、甘油三脂、高密度脂蛋白、低密度脂蛋白、載脂蛋白水平，動脈硬化指數（AI），血流變學指標及患者中醫(yī)癥候變化情況。結果：治療組癥狀改善總有效率為93.33%，顯效率為53.33%，與對照組相比較有顯著性差異(P<0.05)；治療組TC、LDL-C、TG、ApoB明顯降低，HDL-C、A

2、poA1明顯升高，與對照組無差異(P>0.05）。治療組Lp(a)明顯降低，與對照組比較有顯著性差異(P<0.05或0.01)。兩組治療后動脈硬化指數（AI）與血液流變學變化治療組均優(yōu)于對照組，有顯著差異（P<0.05）。結論：固本祛瘀，化痰調脂法是治療老年高脂血癥的一種有效方法，并具有改善血流動力學變化、動脈硬化指數水平以及患者臨床癥狀的作用。關鍵詞老年高脂血癥；固本祛瘀化痰調脂；臨床研究ClinicalResearchonTreatmentofHyperlipidemiaUsingthewayofsupportinghealthyenergy,eliminatingstasis,

3、alleviatingphlegmandregulatinglipidSpeciality：InternalMedicineofTraditionalChineseMedicineAuthor：WangZhilinTutor：Prof.BaoPeirongAbstractObjective:toobservetheclinicalcurativeeffectoftreatingsenilehyperlipidemiainthewayofsupportingenergy,eliminatingstasis,alleviatingphlegmandregulatinglipid,then

4、researchonthemechanismofthemethod.Methods:groupingdoubleblindly,sixtycasesofsenilehyperlipidemiaaredevidedintotwotreatmentgroup,30personeachgroup.Thetreatmentgroupwastreatedwithhealthyenergysupportingsoupand10mgsimvastatin,thecontrolgroupwastreatedwith20mgsimvastatin.Atreatmentperiodlastfor8wee

5、ks.Checkthefollowingindexofpatientsbeforeandafterthetreatment:triglycerides,high-densitylipoproteincholesterol(hdl-c),lowdensitylipoprotein,apolipoproteinlevel,arteriosclerosisindex(AI),hemorrheologyindexandsymptom.Results:effectiverateoftreatmentgroupwhosesymptomwereimprovedwas93.33%,ofwhich53

6、.33%significantly.Comparedwiththecontrolgroup,theTC,LDL-C,TG,ApoBwerereducedsignificantly.hdl-c,ApoA1wereincreasedsignificantly,thesamewiththecontrolgroup.(P>0.05).Lp(a)wasreducedsignificantlyinthetreatmentgroup,withsignificantdifferencecomparingtocontrolgroup.atherosclerosisindex(AI)andthehemo

7、rrheologicintreatmentgroupwerebothbetterthanthecontrolgroup,withnotabledifference(P<0.05).Conclusion:supportingenergy,eliminatingstasis,alleviatingphlegmandregulatinglipidmethodisakindofeffectivemethodontreatingsenilehyperlipidemi