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1、提要目的：本研究是為了觀察健脾安腸湯治療腹瀉型腸易激綜合征（irritablebowelsyndrome，IBS），中醫(yī)辨證為肝郁脾虛型泄瀉的臨床療效，并從理論和臨床研究兩個(gè)方面探討其治療腹瀉型IBS的療效機(jī)制，客觀評(píng)價(jià)其有效性和安全性。方法：臨床選擇符合納入標(biāo)準(zhǔn)的60例IBS患者，按照就診的先后順序隨機(jī)分為試驗(yàn)組和對(duì)照組，其中試驗(yàn)組30例，給予健脾安腸湯治療，對(duì)照組30例，給予得舒特治療，療程4周。對(duì)治療后臨床主要癥狀的改善，治療后、用藥3月后的綜合療效、中醫(yī)證候積分，復(fù)發(fā)率等指標(biāo)進(jìn)行觀察比較。結(jié)果：臨床研究顯示：①試驗(yàn)組與對(duì)照組的綜合療效、中醫(yī)證候總療效，三月后的綜合療效比較有顯著性
2、差異；②試驗(yàn)組在消除或改善泄瀉、胸脅脹悶、食欲不振、脘腹痞滿、抑郁或煩躁，乏力和神疲懶言等癥狀方面的療效優(yōu)于對(duì)照組；③對(duì)照組復(fù)發(fā)率明顯高于試驗(yàn)組，說明健脾安腸湯在根治IBS腹瀉型上更有優(yōu)勢。結(jié)論：健脾安腸湯可以有效地改善腹瀉型IBS患者的臨床癥狀，并能有效減少愈后復(fù)發(fā)。在用藥過程中未發(fā)現(xiàn)有心、肝，腎等重要器官的損害。說明健脾安腸湯是一療效確切，安全無明顯不良反應(yīng)的治療腹瀉型IBS的中藥制劑。關(guān)鍵詞健脾安腸湯；腹瀉型IBS；肝郁脾虛；臨床研究；中醫(yī)藥治療TheclinicalresearchofJianPiAnChangdecoctioninthetreatmentofirritableb
3、owelsyndrometypediarrhea.Speciality:InternalmedicineoftraditionalChinesemedicineAuthor:DuanXiaodongTutor:LiuWeimingAbstractObjectives:ToobserveJianPiAnChangdecoctioninthetreatmentofchronicdiarrheaofStomachtypediarrhea---irritablebowelsyndrometypediarrhea.TheSpleendeficiencystomachtypefortheclinic
4、alcurativeeffectofdiarrhea,andfromthetwoaspectsoftheoryandclinicalresearchintoJianPiAnChangdecoctionintheirritablebowelsyndrometypediarrhea,theeffectivenessandsafety.Theguidanceofitintheclinicalapplication.Methods:Thisresearchwasbasedon60casesofirritablebowelsyndrometypediarrhea.Spleendeficiencyf
5、romtheclinicofthehospitaltoTCMofjinan.Dividedthemrandomlyintotwogroups.Onegroupwasthetreatmentgroup,30patientsweretreatedwithJianPiAnChangdecoction.Andtheothergroupwasthecontrolgroup,with30patientsbeingtreatedwithDeshute.AllthepatientsmettheTCMdiagnosiscriterion.Boththetwogroupsweretreatedforfour
6、weeks.ComparetheeffectiveandtheTCMsyndromeintegralsaftertreatment,forthreemonthsaftertreatmentandtherecurrencerate.Results:ThetreatmentgroupisbetterthanthecontrolgroupintheTCMsyndromeintegralevaluationaftertreatmentandthreemonthsaftersuccedenttreatment.Thecomprehensivecurativeeffectoftreatmentisb
7、etterthanthatofthecontrolgroup.Thetreatmentgrouptoeliminateorimprovereliefindiarrhea,chesttightnessintheexpansionthreat,anorexia,abdominaloftenfull,depressionoranxiousnew,exhaustionandgodexhaustingthesymptomsuchaslazyt
