急性心肌梗死患者溶栓后血漿中腦鈉素濃度變化的研究

《急性心肌梗死患者溶栓后血漿中腦鈉素濃度變化的研究》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。

1、維普資訊http://www.cqvip.com·168中華老年心腦血管病雜志2006年3月第8卷第3期OlnJGerlatrHeartnl'ai$

2、VesselDis，Mar2006．Vol8。No．3．臨床研究．急性心肌梗死患者溶栓后血漿中腦鈉素濃度變化的研究趙雅琳，蔣寶國(1．沈陽醫(yī)學院奉天醫(yī)院，遼寧沈陽110024；2．中國醫(yī)科大學附屬第四醫(yī)院，遼寧沈陽110032)摘要：目的研究血中腦鈉素(BNP)水平與急性心肌梗死溶栓后左心室射血分數(shù)(LVEF)和心肌缺血程度的關(guān)系。方法將198例順序入選的急性心肌梗死行鏈激酶靜脈溶栓治療的患者分為溶栓成功組(105例)和溶栓未成功組(93例

3、)，檢測所有患者的血BNP水平及測定LVEF，比較溶栓成功組與溶栓未成功組LVEF>40％和LVEF~<40％的BNP水平。結(jié)景溶栓成功組BNP水平明顯低于溶栓未成功組的BNP水平(725．4土169．8)ng／L(P<0．05)，溶栓成功組和未成功組中LvEF>40％患者的BNP水平[(107．7土46．5)I1g／L，(488．5土88．9)ng／L]明顯低于LVEF~<40％患者的BNP水平[(515．5±121．2)l1g，L，(856．7土129．5)ng／L，P

4、療法；危險因素中圖分類號：R542．22文獻標識碼：A文章編號：1009—0126(2006103—016803PlasmalevelsofbrainnatriureticpeptideinacutemyocardialinfarctionpatientsafterthrombolysisZHAOYa—lin，JIANGBao—guo(OepaamentofCardiology，F(xiàn)engtlanHospitalAJfiliatedtoShenyangMedicalCollege，Shenyang110024，Ch／na)Abstract：ObjectiveToinvestigatethe

5、relationshipbetweenplasmalevelsofbrainnatriureticpeptide(BNP)andleftventricularejectionfraction(LVEF)anddegreeofmyocardialischemiainpatientswithacutemyocar—dialinfarction(AMI)afterthrombolytictherapy．Methods198AMIpatientstreatedwithintravenousthrum—bolysiswererandomlydividedintotwogroups．BNPconce

6、ntrationofcoronaryrepatencygroupWascomparedththatofmyocardialisehemiagroup，andthatofLVEF>40％withthatofLVEF~<40％patientsrespective—lyintwogroups．ResultsPlasmaBNPconcentrationincoronaryrepatencygroupWassignificantlylowerthanthatinmyocardialischemlagroup[(327．9土85．4)(725．4±169．8)ng／L，P<0．05]．Ineomna

7、ryrepa—tencygroup，plasmaBNPconcentrationWas(107．7±46．5)ng／LinLVEF>40％patientsand(515．5-4-121．2)nggLinLVEF_<_40％patients．Inmyocardialisehemiagroup，plasmaBNPconcentrationinLVEF>40％patientswassignificantlylowerthanthatinLVEF~<40％patients[(488．5±88．9)ng／L(856．7-4-129+5)nggL](P

8、NPconcentrationisrelatedtoLVEFandthedegreeofmyocardialisehemiaafterthrombolytietherapyforacutemyocardialinfarction．Keywords：CDDCDDCDDCDDmyocardialinfarction；natriureticpeptide，brain；thmmbolytietherapy；riskfactors近年來，急診