不同程度母愛剝奪對成年大鼠學(xué)習(xí)記憶影響的實(shí)驗(yàn)分析

《不同程度母愛剝奪對成年大鼠學(xué)習(xí)記憶影響的實(shí)驗(yàn)分析》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。

1、萬方數(shù)據(jù)英文捅要一——————————————————————————————————————————————一leamingandmemoryinratsandexploreitspossibleneuro。biologicalmechanisms．Methods：Theneonatalrats7daysafterbinhwererandomlydividedintonormalcontrolgroup(Con)，partialmaternalseparationgroup(PMS)andcompletematernalseparationgroup(CMS)．T

2、oobservetheeffectsofmaternalseparationontheleamingandmemoryofadultratsbyusingMorriswatermaze，toshowthedamageofneuronsinhippocampusCAlareabyNisslstaininganddetectmemalondialdehyde(MDA)andsuperoxidedismutase(SOD)inhippocampus．Results：TheescapelatentperiodofPMSratswaslongerthanthatinCongr

3、ouponthirdday(PO．05、)：TheescapelatentperiodofCMSratswaslongerthanthatinCongroup(P<0．05)，thetimesofcrossingplatformandtheswimmingtimeintheDlatformareawerereduced(P<0．05)comparedwithCongroupandP

4、MSgroup，thedamageofneuronsinCA1areawasaggravated，ComparedwithCongroup．MDAwasincreased(P

5、ybeoneoftheneurobiologicalmechanismsofthereductionoflearningandmemoryinratadulthood．Thedegreeofmatemalseparationisdeeper,thelearningandmemoryofadultratsdecreasedmore，whichmaybetheresultfromtheneurondamageofthehippocampusCA1areacausedbyexcessiveaccumulationofoxygenfreeradicalinratbrain．

6、Keywords：Earlymaternalseparation，rat，learningandmemory,hippocampus，MDA，SOD-——————————————————————————————————————————————————一4萬方數(shù)據(jù)英文縮寫ELSMSMDASODConPMSCMSfM對HPCearlylifestress早期生命應(yīng)激癥maternalseparation母愛剝奪malondialdehyde丙二醛superoxidedismutase超氧化物歧化酶controlgroup對照組partialmaternalseparat

7、iongroup部分母嬰分離組completematernalseparationgroup完全母嬰分離組FunctionalMRJ功能性磁共振成像研究Hippocampus海馬5萬方數(shù)據(jù)研究論文不同程度母愛剝奪對成年大鼠學(xué)習(xí)記憶影響的實(shí)驗(yàn)研究-▲上--J_刖吾研究表明人類生命早期應(yīng)激(earlylifetimeevents，ELS)是成年后多種行為異?！?’3】及多種精神疾病的重要風(fēng)險(xiǎn)因素，可誘發(fā)嚴(yán)重抑郁癥(ma]ordepression)、物質(zhì)使用障礙(substanceusedisorder)、創(chuàng)傷后應(yīng)激障礙(，posttraumaticstressdis