不同程度母愛剝奪對(duì)成年大鼠學(xué)習(xí)記憶影響的實(shí)驗(yàn)研究

不同程度母愛剝奪對(duì)成年大鼠學(xué)習(xí)記憶影響的實(shí)驗(yàn)研究

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不同程度母愛剝奪對(duì)成年大鼠學(xué)習(xí)記憶影響的實(shí)驗(yàn)研究_第1頁
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1、授予單位代碼10089學(xué)號(hào)或申請(qǐng)?zhí)?3918HebeiMedicalUniversity碩士學(xué)位論文在職科學(xué)學(xué)位不同程度母愛剝奪對(duì)成年大鼠學(xué)習(xí)記憶影響的實(shí)驗(yàn)研究作者姓名:葛晶導(dǎo)師:李雙成副教授專業(yè):人體解剖與組織胚胎學(xué)二級(jí)學(xué)院:基礎(chǔ)醫(yī)學(xué)院2015年03月河北醫(yī)科大學(xué)學(xué)位論文使用授權(quán)及知識(shí)產(chǎn)權(quán)歸屬承諾本學(xué)位論文在導(dǎo)師(或指導(dǎo)小組)的指導(dǎo)下,由本人獨(dú)立完成。本學(xué)位論文研究所獲得的研究成果,其知識(shí)產(chǎn)權(quán)歸河北醫(yī)科大學(xué)所有。河北醫(yī)科大學(xué)有權(quán)對(duì)本學(xué)位論文進(jìn)行交流、公開和使用。凡發(fā)表與學(xué)位論文主要內(nèi)容相關(guān)的論文,第一署名為單

2、位河北醫(yī)科大學(xué),試驗(yàn)材料、原始數(shù)據(jù)、申報(bào)的專利等知識(shí)產(chǎn)權(quán)均歸河北醫(yī)科大學(xué)所有。否則,承擔(dān)相應(yīng)法律責(zé)任。研究生簽名:I‘導(dǎo)師簽章級(jí)學(xué)院領(lǐng)導(dǎo)蓋章:2oiJ年J月k日河北醫(yī)科大學(xué)研究生學(xué)位論文獨(dú)創(chuàng)性聲明本論文是在導(dǎo)師指導(dǎo)下進(jìn)行的研究工作及取得的研究成果,除了文中特別加以標(biāo)注和致謝等內(nèi)容外,文中不包含其他人已經(jīng)發(fā)表或撰寫的研究成果,指導(dǎo)教師對(duì)此進(jìn)行了審定。本論文由本人獨(dú)立撰寫,文責(zé)自負(fù)。年目錄中文摘要····························································

3、·················1英文摘要·············································································3英文縮寫·············································································5研究論文不同程度母愛剝奪對(duì)成年大鼠學(xué)習(xí)記憶影響的實(shí)驗(yàn)研究前言··············································

4、·······························6材料與方法····································································7結(jié)果·············································································9附圖······································································

5、·······12附表·············································································14討論·············································································15結(jié)論·············································································18參考文獻(xiàn)··

6、·····································································18綜述海馬持續(xù)記憶的預(yù)期性與回顧性:時(shí)間優(yōu)先?····················21致謝···················································································44個(gè)人簡(jiǎn)歷····················································

7、·························45中文摘要不同程度母愛剝奪對(duì)成年大鼠學(xué)習(xí)記憶影響的實(shí)驗(yàn)研究摘要許多研究表明人類生命早期應(yīng)激(earlylifetimeevents,ELS)是成年后行為學(xué)及多種精神疾病的重要風(fēng)險(xiǎn)因素,可誘發(fā)嚴(yán)重抑郁癥(majordepression)、物質(zhì)使用障礙(substanceusedisorder)、創(chuàng)傷后應(yīng)激障礙(posttraumaticstressdisorder)、認(rèn)知缺陷(cognitivedeficit)、兒童注意缺陷癥(childrenattention

8、deficit)及精神分裂癥(schizophrenia)等疾病,但是其內(nèi)在機(jī)制我們知之甚少。近來關(guān)于其致病機(jī)制的研究主要集中在神經(jīng)內(nèi)分泌系統(tǒng),由于道德的約束及方法學(xué)的限制,以人為對(duì)象的研究還是有限的。為了進(jìn)一步深入、全面地探討生命早期應(yīng)激引起人類精神疾病發(fā)病的機(jī)制的研究,現(xiàn)在主要采用動(dòng)物模型。其中,應(yīng)用于嚙齒類動(dòng)物的母愛剝奪(母嬰分離maternalseparation,MS)模型,

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