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1、分類號學號M201075488學校代碼10487密級碩士學位論文單次鼻腔給予胰島素對異丙酚引起的tau蛋白過度磷酸化影響的實驗研究學位申請人：王佳佳學科專業(yè)：神經(jīng)病學指導教師：梁直厚副教授答辯日期：2013年5月ADissertationSubmittedinPartialFulfillmentoftheRequirementsfortheDegreeofMasterofmedicineResearchoneffectofsingleintranasalinsulindeliveryonpropofolinducedtauhyperphosphorylation
2、Candidate:WangJiajiaMajor:NeurologySupervisor:LiangZhihouHuazhongUniversityofScienceandTechnologyWuhan,Hubei430074,P.R.ChinaMay,2013獨創(chuàng)性聲明本人鄭重聲明，本學位論文是本人在導師指導下進行的研究工作及取得的研究成果的總結。盡我所知，除文中已經(jīng)標明引用的內容外，本論文不包含任何其他個人或集體已經(jīng)發(fā)表或撰寫過的研究成果。對本文的研究做出貢獻的個人和集體，均已在文中以明確方式標明。本人完全意識到本人將承擔本聲明引起的一切法律后果。學位論文
3、作者簽名：日期：年月日學位論文版權使用授權書本學位論文作者完全了解學校有關保留、使用學位論文的規(guī)定，即：學校有權保留并向國家有關部門或機構送交論文的復印件和電子版，允許論文被查閱和借閱。本人授權華中科技大學可以將本學位論文的全部或部分內容編入有關數(shù)據(jù)庫進行檢索，可以采用影印、縮印或掃描等復制手段保存和匯編本學位論文。保密□，在_____年解密后適用本授權書。本論文屬于不保密□。（請在以上方框內打“√”）學位論文作者簽名：指導教師簽名：日期：年月日日期：年月日目錄摘要·················································
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5、···························································································5實驗結果···································································································10討論·····················································································
6、···············15參考文獻···································································································17全文小結···································································································20綜述胰島素信號通路障礙與阿爾茨海默病·······································
7、····21致謝····································································································26華中科技大學碩士學位論文單次鼻腔給予胰島素對異丙酚引起的tau蛋白過度磷酸化影響的實驗研究摘要目的：探討單次鼻腔給予胰島素對異丙酚引起的tau蛋白過度磷酸化的影響及機制。方法：SD大鼠，雄性,8周，給予以下處理：鼻腔給予胰島素（3ml:300IU）或生理鹽水42μl,半小時后腹腔注射異丙酚150mg/kg或等體積脂肪乳，一個小時后頸椎脫臼法處死，
8、取雙側海馬組織，通過We
