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1、孕期、哺乳期暴露十溴聯(lián)苯醚對(duì)子代大鼠免疫功能的影響作者：周俊1；陳敦金2；廖秦平2；余艷紅1 (1南方醫(yī)科大學(xué)南方醫(yī)院婦產(chǎn)科，廣東??廣州??510515；2北京大學(xué)第一醫(yī)院婦產(chǎn)科，北京??100710)摘要：目的針對(duì)環(huán)境污染中十溴聯(lián)苯醚對(duì)母嬰健康存在潛在危害日益受到重視，研究經(jīng)口胃灌十溴聯(lián)苯醚對(duì)子代大鼠免疫功能的影響。方法對(duì)母代孕期前后及哺乳期持續(xù)高劑量胃灌十溴聯(lián)苯醚后，觀(guān)察其子代大鼠免疫器官發(fā)育情況、T淋巴細(xì)胞亞群及T淋巴細(xì)胞增殖轉(zhuǎn)化功能、NK細(xì)胞表面分子CD161表達(dá)及免疫球蛋白(IgM、IgG)等變化。結(jié)果實(shí)驗(yàn)組免疫器官質(zhì)量與對(duì)照組相比有變化，其T淋巴細(xì)胞亞群CD3+、C
2、D3+CD8+、CD3+CD4+及NK細(xì)胞表面分子CD161+百分比、CD4+/CD8+比值下降，CD4-CD8-百分比升高。實(shí)驗(yàn)組T淋巴細(xì)胞增殖轉(zhuǎn)化功能下降不明顯，其IgM含量明顯低于對(duì)照組，IgG含量變化不明顯。結(jié)論母代持續(xù)暴露高劑量十溴聯(lián)苯醚后，對(duì)子代免疫功能存在一定的不利影響。關(guān)鍵詞：十溴聯(lián)苯醚；免疫功能；大鼠中圖分類(lèi)號(hào)：R71??文獻(xiàn)標(biāo)識(shí)碼：A??文章編號(hào)：1673-4254(2006)06-0738-04ImpactofPBDE-209exposureduringpregnancyandlactationonimmunefunctionofoffspringratsZH
3、OUJun1；CHENDun-jin2；LIAOQin-ping2；YUYan-hong11DepartmentofGynecologyandObstetrics,NanfangHospital,SouthernMedicalUniversity,Guangzhou510515,China;2DepartmentofGynecologyandObstetrics,FirstAffiliatedHospital,BeijingMedicalUniversity,Beijing100710,ChinaAbstract:ObjectiveToassessthepotentialhazar
4、dofenvironmentaldeca-brominateddiphenylether(PBDE-209)exposuretotheimmunefunctionoftheoffspringrats.MethodsTheparentalWistarratswereexposedtoPBDE-209administeredintragastricallyduringpregnancyandlactation,andthedevelopmentoftheimmuneorgansandchangesinTlymphocytesubsetandtheirproliferation,NKce
5、llsurfacemarkersCD161andserumimmunoglobulins(IgMandIgG)wereobserved.ResultsSignificantdifferencesintheweightoftheimmuneorganswerenotedbetweentheexposuregroupandcontrolgroup.Intheexposuregroup,thepercentageofTlymphocytesubsetCD3+,CD4+,CD8+,CD4+CD8+,thepercentageofNKcellsurfacemarkersCD161andCD4
6、+/CD8+ratiowerelowered,whilethepercentageofCD4-CD8-cellsincreased.Tlymphocytesubsetproliferationintheexposuregroupdidnotshowobviouslychanges,butcomparedwiththecontrolgroup,theIgMlevelintheexposuregroupwassignificantlylowered.NosignificanrdifferenceswereobservedinIgGlevelsbetweentheexposureandc
7、ontrolgroups.ConclusionContinuousexposuretohigh-dosePBDE-209infemaleratsduringpregnancyandlactationresultsinpossibleadverseeffectontheimmunefunctionoftheoffspringrats.Keywords:deca-brominateddiphenylether;immunefunction;rats收稿日期：2006-01
