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1、孕期、哺乳期暴露十溴聯(lián)苯醚對子代大鼠免疫功能的影響作者：周俊1；陳敦金2；廖秦平2；余艷紅1 (1南方醫(yī)科大學(xué)南方醫(yī)院婦產(chǎn)科，廣東??廣州??510515；2北京大學(xué)第一醫(yī)院婦產(chǎn)科，北京??100710)摘要：目的針對環(huán)境污染中十溴聯(lián)苯醚對母嬰健康存在潛在危害日益受到重視，研究經(jīng)口胃灌十溴聯(lián)苯醚對子代大鼠免疫功能的影響。方法對母代孕期前后及哺乳期持續(xù)高劑量胃灌十溴聯(lián)苯醚后，觀察其子代大鼠免疫器官發(fā)育情況、T淋巴細(xì)胞亞群及T淋巴細(xì)胞增殖轉(zhuǎn)化功能、NK細(xì)胞表面分子CD161表達及免疫球蛋白(IgM、IgG)等變化。結(jié)果實驗組免疫器官質(zhì)量與對照組相比有變
2、化，其T淋巴細(xì)胞亞群CD3+、CD3+CD8+、CD3+CD4+及NK細(xì)胞表面分子CD161+百分比、CD4+/CD8+比值下降，CD4-CD8-百分比升高。實驗組T淋巴細(xì)胞增殖轉(zhuǎn)化功能下降不明顯，其IgM含量明顯低于對照組，IgG含量變化不明顯。結(jié)論母代持續(xù)暴露高劑量十溴聯(lián)苯醚后，對子代免疫功能存在一定的不利影響。關(guān)鍵詞：十溴聯(lián)苯醚；免疫功能；大鼠中圖分類號：R71??文獻標(biāo)識碼：A??文章編號：1673-4254(2006)06-0738-04ImpactofPBDE-209exposureduringpregnancyandlactationo
3、nimmunefunctionofoffspringratsZHOUJun1；CHENDun-jin2；LIAOQin-ping2；YUYan-hong11DepartmentofGynecologyandObstetrics,NanfangHospital,SouthernMedicalUniversity,Guangzhou510515,China;2DepartmentofGynecologyandObstetrics,FirstAffiliatedHospital,BeijingMedicalUniversity,Beijing100710,
4、ChinaAbstract:ObjectiveToassessthepotentialhazardofenvironmentaldeca-brominateddiphenylether(PBDE-209)exposuretotheimmunefunctionoftheoffspringrats.MethodsTheparentalWistarratswereexposedtoPBDE-209administeredintragastricallyduringpregnancyandlactation,andthedevelopmentoftheimm
5、uneorgansandchangesinTlymphocytesubsetandtheirproliferation,NKcellsurfacemarkersCD161andserumimmunoglobulins(IgMandIgG)wereobserved.ResultsSignificantdifferencesintheweightoftheimmuneorganswerenotedbetweentheexposuregroupandcontrolgroup.Intheexposuregroup,thepercentageofTlympho
6、cytesubsetCD3+,CD4+,CD8+,CD4+CD8+,thepercentageofNKcellsurfacemarkersCD161andCD4+/CD8+ratiowerelowered,whilethepercentageofCD4-CD8-cellsincreased.Tlymphocytesubsetproliferationintheexposuregroupdidnotshowobviouslychanges,butcomparedwiththecontrolgroup,theIgMlevelintheexposuregr
7、oupwassignificantlylowered.NosignificanrdifferenceswereobservedinIgGlevelsbetweentheexposureandcontrolgroups.ConclusionContinuousexposuretohigh-dosePBDE-209infemaleratsduringpregnancyandlactationresultsinpossibleadverseeffectontheimmunefunctionoftheoffspringrats.Keywords:deca-b
8、rominateddiphenylether;immunefunction;rats收稿日期：2006-01
