難治性癲癇患者認(rèn)知功能評(píng)估及影響因素分析

難治性癲癇患者認(rèn)知功能評(píng)估及影響因素分析

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時(shí)間:2019-03-14

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1、授予單位代碼10089學(xué)號(hào)或申請(qǐng)?zhí)枴?0122540蚵於(E鈄大5HebeiMedicalUniversity碩士學(xué)位論文科學(xué)學(xué)位難治性癲癇患者認(rèn)知功能評(píng)估及影響因素分析研究生:張波導(dǎo)師:趙文清教授李文玲教授專(zhuān)業(yè):外科學(xué)二級(jí)學(xué)院:河北省人民醫(yī)院河北醫(yī)科大學(xué)學(xué)位論文使用授權(quán)及知識(shí)產(chǎn)權(quán)歸屬承諾本學(xué)位論文在導(dǎo)師(或指導(dǎo)小組)的指導(dǎo)下,由本人獨(dú)立完成。本學(xué)位論文研究所獲得的研宄成果,其知識(shí)產(chǎn)權(quán)歸河北醫(yī)科大學(xué)所有。河北醫(yī)科大學(xué)有權(quán)對(duì)本學(xué)位論文進(jìn)行交流、公開(kāi)和使用。凡發(fā)表與學(xué)位論文主要內(nèi)容相關(guān)的論文,第一署名為單位河北醫(yī)科大學(xué),試驗(yàn)材料、原始數(shù)據(jù)、申報(bào)的專(zhuān)利等知識(shí)產(chǎn)權(quán)均歸河北醫(yī)科大學(xué)所有。否則,承擔(dān)相

2、應(yīng)法律責(zé)任。研宂生簽名導(dǎo)師簽章:二級(jí)學(xué)院領(lǐng)導(dǎo)蓋章:lyo丨’年j月4河北醫(yī)科大學(xué)研究生學(xué)位論文獨(dú)創(chuàng)性聲明本論文是在導(dǎo)師指導(dǎo)下進(jìn)行的研究工作及取得的研宄成果,除了文中特別加以標(biāo)注和致謝等內(nèi)容外,文中不包含其他人已經(jīng)發(fā)表或撰寫(xiě)的研究成果,指導(dǎo)教師對(duì)此進(jìn)行了審定。本論文由本人獨(dú)立撰寫(xiě),文責(zé)自負(fù)。目錄中文摘要··············································································1英文摘要································································

3、··············4英文縮寫(xiě)··············································································7研究論文難治性癲癇患者認(rèn)知功能評(píng)估及影響因素分析前言··············································································8材料與方法·····································································9結(jié)果··················

4、···························································14附圖·············································································16附表·············································································21討論·········································································

5、····25結(jié)論·············································································30參考文獻(xiàn)·······································································31綜述癲癇與認(rèn)知·································································35致謝··························································

6、·························52個(gè)人簡(jiǎn)歷·············································································53中文摘要難治性癲癇患者認(rèn)知功能評(píng)估及影響因素分析摘要背景:癲癇是中樞神經(jīng)系統(tǒng)中僅次于腦血管病的第二常見(jiàn)病,世界各地的報(bào)告顯示癲癇發(fā)病率約為20-50/10萬(wàn)/年。據(jù)世界衛(wèi)生組織估計(jì)全球大約有5000萬(wàn)癲癇患者。根據(jù)調(diào)查,我國(guó)的發(fā)病率約為35/10萬(wàn)/年,患病率約為0.4%,高發(fā)區(qū)甚至達(dá)1%,大約有600萬(wàn)癲癇患者,同時(shí)每年新增癲癇患者約40萬(wàn)。在癲癇患者中,有20%-30%

7、的患者通過(guò)藥物治療不能有效控制,稱(chēng)為難治性癲癇。癲癇不僅給患者的生活和工作帶來(lái)了嚴(yán)重的影響,同時(shí)也給家庭、社會(huì)帶來(lái)了沉重的負(fù)擔(dān)。癲癇的反復(fù)發(fā)作可以嚴(yán)重影響患者的認(rèn)知功能。認(rèn)知功能指人類(lèi)各種有意識(shí)的精神活動(dòng),學(xué)習(xí)知識(shí)、運(yùn)用知識(shí)的能力,包括計(jì)算能力、抽象概括能力、判斷能力、記憶力等多種能力。據(jù)報(bào)道,80%以上的癲癇患者認(rèn)知功能低于正常人,其中[1]50%以上具有明顯認(rèn)知功能缺陷,癲癇與認(rèn)知功能的關(guān)系是目前臨床和科研的研究熱點(diǎn)

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