資源描述：
《txnip在uuo小鼠腎間質(zhì)纖維化中的作用》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在學術(shù)論文-天天文庫。
1、授予單位代碼10089學號或申請?zhí)朒ebeiMedicalUniversity碩士學位論文科學學位TXNIP在UUO小鼠腎間質(zhì)纖維化中的作用作者姓名：安洋導師：史永紅教授專業(yè)：病理學與病理生理學二級學院：基礎(chǔ)醫(yī)學院2015年03月河北醫(yī)科大學學位論文使用授權(quán)及知識產(chǎn)權(quán)歸屬承諾本學位論文在導師（或指導小組）的指導下，由本人獨立完成。本學位論文研究所獲得的研究成果，其知識產(chǎn)權(quán)歸河北醫(yī)科大學所有。河北醫(yī)科大學有權(quán)對本學位論文進行交流、公開和使用。凡發(fā)表與學位論文主要內(nèi)容相關(guān)的論文，第一署名為單位河北醫(yī)科大學，試
2、驗材料、原始數(shù)據(jù)、申報的專利等知識產(chǎn)權(quán)均歸河北醫(yī)科大學所有。否則，承擔相應(yīng)法律責任。研究生簽名：導師簽章：逆永化二級學院領(lǐng)導蓋章年/P-呷河北醫(yī)科大學研究生學位論文獨創(chuàng)性聲明本論文是在導師指導下進行的研究工作及取得的研究成果，除了文中特別加以標注和致謝等內(nèi)容外，文中不包含其他人已經(jīng)發(fā)表或撰寫的研究成果，指導教師對此進行了審定。本論文由本人獨立撰寫，文責自負。年玄月j曰目錄中文摘要································································
3、·············1英文摘要·············································································4英文縮寫·············································································7研究論文TXNIP在UUO小鼠腎間質(zhì)纖維化中的作用前言··················································
4、···························8材料與方法····································································9結(jié)果·············································································15附圖······································································
5、·······16附表·············································································16討論·············································································19結(jié)論·············································································26參考文
6、獻·······································································26綜述TXNIP在疾病中的作用及調(diào)節(jié)機制····································29致謝···················································································38個人簡歷·································
7、············································39中?文?摘?要TXNIP在UUO小鼠腎間質(zhì)纖維化中的作用摘要目的：腎臟間質(zhì)纖維化是各種腎臟病變進展到慢性腎衰竭的共同過程，其主要特征是腎臟內(nèi)固有細胞纖維化以及細胞外基質(zhì)蛋白的異常堆積。多種分子機制及信號通路參與其進程，包括TGF-β1激活、腎小管上皮細胞的向間充質(zhì)細胞轉(zhuǎn)化、細胞外基質(zhì)包括纖維連接蛋白、膠原(I,III,IV,V和VII型)等的堆積，發(fā)揮了重要的作用。硫氧還蛋白相互作用蛋白（thioredoxinin
8、teractingprotein,TXNIP）是一種硫氧還蛋白（thioredoxin，TRX）的內(nèi)源性抑制蛋白，能夠通過與其結(jié)合抑制其功能。有研究顯示，在高糖誘導的HK-2細胞中，敲低TXNIP能夠增加的TRX活性，從而抑制高糖誘導的氧化應(yīng)激，抑制小管細胞TGF-β信號通路的激活，下調(diào)纖維連接蛋白（fibronectin，F(xiàn)N）的表達。在高糖誘導的系膜細胞中，敲低TXNIP能夠抑制高糖誘導的纖連蛋白表達。新近的一項研究顯示，
