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1、艾司西瞅普蘭與舍曲林治療重度抑郁癥療效比較李華榮(聊城市第四人民醫(yī)院,山東聊城252000)抗抑郁藥;艾司西駄普蘭;重度抑郁癥;舍曲林;[摘要]目的比較艾司四臥普蘭與舍曲林對匣度抑郁癥的療效及安金性。方法125例抑郁癥分為2組。艾司西猷普蘭組63例[男性30例,女性33例,年齡(36±12)歲,木次抑郁癥期(3±4)mol給予艾司西瞰普蘭10?20mg,pofqd;舍曲林組62例[男性28例,女性34例,年齡(40±11)歲,本次抑郁癥期(3±4)mo]給予舍曲林50?100mg,“0,qd;均6wk為一個(gè)療程。結(jié)果對抑郁癥狀的治療,艾司四猷普蘭組顯效
2、率為71%,舍曲林組顯效率74%,2組療效比較差異無顯著意義(P>o.05);對伴隨焦慮癥狀的治療,艾司西駄普蘭組顯效率48%,舍曲林組顯效率45%,2組療效比較差異無顯著意義(P>0.05)o藥物不良反應(yīng)發(fā)生率2組相當(dāng)。結(jié)論艾司西駄普蘭與舍曲林療效相當(dāng),能冇效治療重度抑郁癥及伴隨焦慮癥狀,不良反應(yīng)輕微。[中圖分類號1R971.4[文獻(xiàn)標(biāo)識碼]ComparativestudyofescitalopramandsertralineinSeveredepressiondisorderLIHua-rong(TheFouthpcoolcsHospitalofL
3、iaochcngMunicipal,LiaochcngSI1AN-D0NG252000,China)[KEYWORDS]antidepressiveagents;escitalopram;Severedepression;sertraline[ABSTRACTIAIMEsmololcomparisonofescitaiopramandsertralineforseveredepression,theefficacyandsafety.METHODS125casesofdepressionweredividedinto2groups,escitalopr
4、amgroupof63patients[male30cases,female33cases,age(36±12)yearsofage,thisdepressionperiod(3土4)mo]togiveescitalopram10?20mg,po,qd;sertralinegroupof62cases[28casesofmale,female34cases,age(40土11)yearsofage,thisdepressionperiod(3±4)mo]givcnsertralinc50?100mg,po,qd;are6wkasacourseoftre
5、atment.RESULTSSymptomsofdepressiontreatment,escitalopramgroupwere71%efficiency,theefficiencyofsertralinegroupwere74%,Group2efficacywasnosignificantdifferenee(P>0.05);pairsofanxietysymptomsassociatedwiththetrcatment,escitalopramgroupwere48%efficiency,theefficiencyofsertralinegrou
6、pwere45%efficacydifferencebetweentwogroupswasnotsignificant(P>0.05).Theincidenceofadversedrugreactionrathertwogroups.CONCLUSIONescitalopramandsertralineefficacyequivalenttotheeffectivetreatmentofseveredepressionandanxietysymptomsassociatedwithmildadversereactions.艾司西猷普蘭(escitalo
7、pram)為選擇性5男色胺再攝取抑制(SSRI),艾司西駄普蘭是西瞅普蘭左旋對映體,與5?HT轉(zhuǎn)動(dòng)體異構(gòu)位點(diǎn)親和力高,增加了與基本結(jié)合位點(diǎn)的結(jié)合時(shí)間與強(qiáng)度,增強(qiáng)了5?HT再攝取的抑制,其作用為西軌普蘭右旋對映體作用的100倍,而對去甲腎上腺素和多巴胺再攝取作用微弱。艾司西駄普蘭增進(jìn)中樞神經(jīng)系統(tǒng)5男色胺(5-HT)能的作用,抑制5弄色胺的再攝取,臨床用于抑郁癥的治療⑴。木研究通過對照比較艾司西瞰普蘭與舍曲林治療重度抑郁癥的療效,觀察艾司西瞅普蘭的臨床療效和安全性。資料與方法病例選擇入組標(biāo)準(zhǔn):(1)符合屮國精神疾病分類與診斷標(biāo)準(zhǔn)第3版診斷為抑郁癥。(2)漢
8、密爾頓抑郁量表(HAMD)24版本前17項(xiàng)總分218分。(3)病人停用鋰鹽和三環(huán)類抗抑郁藥(T