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1、現(xiàn)代食品科技ModernFoodScienceandTechnology2015,Vol.31,No.6蕎麥粉對高脂膳食大鼠脂代謝的影響1,21,211,21,2王丹，葛洪娟，張笑，張嵐，宋春梅（1.吉林醫(yī)藥學(xué)院公共衛(wèi)生學(xué)院，吉林吉林132013）（2.吉林省中醫(yī)藥管理局二級實(shí)驗(yàn)室，吉林吉林132013）摘要：本文研究了蕎麥粉（buckwheat，BW）對高脂膳食大鼠脂代謝的影響。將50只成年Wistar雄性大鼠隨機(jī)分為基礎(chǔ)對照組、高脂模型組、蕎麥粉低、中、高劑量組（1、5、10g/kg·d），每天喂食一次，飼喂30d后腹主動(dòng)脈取血，取出肝臟、腎周及睪丸附近脂肪，分別
2、測定血清和肝臟中的總膽固醇(TC)、甘油三酯(TG)、高密度脂蛋白膽固醇(HDL-C)和低密度脂蛋白膽固醇(LDL-C)的水平，并觀察肝臟病理切片。結(jié)果表明，與高脂膳食組相比，蕎麥劑量組大鼠體重和食物攝入量都明顯減少，肝重和脂肪重及其指數(shù)也明顯降低，血清和肝臟中TC、TG、LDL-C的濃度降低，HDL-C的濃度升高。肝臟光鏡結(jié)構(gòu)表明，蕎麥劑量組的肝臟脂肪變性均減輕，其中蕎麥粉高劑量作用最為明顯。說明蕎麥粉干預(yù)高脂膳食，可起到降血脂、改善肝臟脂代謝、保護(hù)肝臟的作用，同時(shí)能夠減少相關(guān)疾病的發(fā)生。關(guān)鍵詞：蕎麥粉；高脂膳食；脂代謝；光鏡結(jié)構(gòu)文章篇號(hào)：1673-9078(201
3、5)6-23-28DOI:10.13982/j.mfst.1673-9078.2015.6.005EffectofBuckwheatonLipidMetabolisminHigh-fatDiet-fedRats1,21,211,21,2WANGDan,GEHong-juan,ZHANGXiao,ZHANGLan,SONGChun-mei(1.DepartmentofPublicandHealth,JinlinMedicalcollege,Jilin132013,China)(2.LeverTwoLaboratoryofAdministrationofTradition
4、alChineseMedicineofJilinProvince,JinlinMedicalcollege,Jilin132013,China)Abstract:Theaimofthisstudywastoelucidatetheeffectofbuckwheat(BW)onlipidmetabolisminhigh-fatdiet-fedrats.Fiftymaleratswererandomlydividedintothefollowinggroups:controldiet,high-fatdiet(HFD),low-doseBW(1g/kg·d),medium
5、doseBW(5g/kg·d),andhighdoseBW(10g/kg·d).Theratswerefedonceadayfor30days.Bloodsamplesweresubsequentlycollectedfromtheposteriorabdominalaorta,andtheliver,inaddition,perirenalfat,andepididymalfatwerecollected.Thelevelsoftotalcholesterol(TC),triglycerides(TG),highdensitylipoproteincholester
6、ol(HDL-C),andlowdensitylipoproteincholesterol(LDL-C)intheserumandliverweremeasured,andpathologicalsectionsofthelivertissueswereobserved.TheresultsshowedthatcomparedtotheHFDgroup,theweightandfoodintakeofalltheBWgroupsweresignificantlylower,theweightsandindexesoftheliverandfattissueswerea
7、lsosignificantlyreduced,theconcentrationofTC,TG,andLDL-Cintheserumandliverweredecreased,andtheconcentrationofHDL-Cwasincreased.Meanwhile,theliverstructureobservedunderthelightmicroscopeshowedthathepaticsteatosisinallBWgroupswasalleviated,withthemostsignificanteffectobservedinth
