SNAIL蛋白表達(dá)與肝細(xì)胞癌術(shù)后預(yù)后的相關(guān)性研究

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1、肝膽外科雜志2010年4月第18卷第2期JournalofHepatobiliarySurgery，Vol，18，No．2，Apr．2010131·基礎(chǔ)研究·Snail蛋白表達(dá)與肝細(xì)胞癌術(shù)后預(yù)后的相關(guān)性研究夏勇，李俊，施樂(lè)華【摘要】目的研究Snail蛋白在肝細(xì)胞癌(HCC)中的表達(dá)及其與臨床病理特征和術(shù)后預(yù)后的關(guān)系。方法應(yīng)用免疫組織化學(xué)sP法，檢測(cè)Snail蛋白在103例肝細(xì)胞癌及25例正常肝組織中的表達(dá)及其在細(xì)胞中的定位。結(jié)果Snail蛋白高度表達(dá)于肝癌組織的細(xì)胞核、細(xì)胞質(zhì)，正常肝組織中表達(dá)較少甚至不

2、表達(dá)，陽(yáng)性率分別為51．5％和16％，兩者差異有統(tǒng)計(jì)學(xué)意義(P<0．05)。Snail在肝癌中的高表達(dá)與肝癌的pTNM分期、腫瘤有無(wú)包膜和微血管侵犯有關(guān)(P<0．05)。結(jié)論HCC患者的術(shù)后的預(yù)后與Snail蛋白的表達(dá)有關(guān)，Snail蛋白有可能成為肝癌術(shù)后預(yù)測(cè)復(fù)發(fā)判斷預(yù)后的生物學(xué)標(biāo)志。【關(guān)鍵詞】肝細(xì)胞癌，預(yù)后，生存，蛋白表達(dá)，Snail蛋白【中圖分類(lèi)號(hào)】R735．7【文獻(xiàn)標(biāo)識(shí)碼】A【文章編號(hào)】1006-4761(2010)02-0131-03RELATIONSHIPBETWEENSNAILPROTEIN

3、EXPRESSIoNANDPROGN0SISOFHEPAToCELLULARCARCINO-MAAFTERHEPATECTOMY(XIAy0，LIJun，SHILe—hua．TheFirstDepartmentofComprehensiveTreatment，EasternHepa—tobiliarySurgeryHospital，SecondMilitaryMedicalUniversity，Shanghai200438，China)【Abstact】ObjectiveToresearchtheexp

4、ressionofSnailproteininHepatocellularCarcinama(HCC)anditscorrelationwiththec1inicopath0localcharacteristicsandprognosisafterhepatectomy．MethodsImmunohistochemicalSPmethodwasusedtoassesstheexpressionofSnailproteinin103easesofHCCtissuesand25casesnormallive

5、rtissues．TheclinieopathologicalfeaturesofHCCwerealsocollectedandquantified．TherelationshipbetweenSnailproteinexpressionandprognosisaftersurgerywasinvestigated．Re-suitsSnaillocatedmainlyinplasmaofHCCcells．SnailhadhigherexpressioninHCCandalmostnoexpression

6、innormaltissue．ThepositiverateofSnailinHCCwas51．5％，whichwassignificantlyhigherthanthatinnormallivertissue(16％，P<0．05)．Theexpres—sionofSnailinHCCwassignificantlyrelatedwithpTNMstaging，with／withouttumorcapsule，andwith／withoutmicrovascularinvasion(P<0．05)．T

7、he5-yearoverallsurvivalratewassignificantlowerintheHCCcaseswiththepositivelyexpressionofSnailthanintheHCCcaseswithnegativelyexpression(P<0．05)．ConclusionTheprognosisandoverallsurvivalarecorrelatedwiththeexpressionofSnailprotein．Snialmightbeanimportantbio

8、logicalmarkerforprognosisofHCCaftersurgery．【Keywords】hepatocellularcarcinoma；prognosis；survival；proteinexpression；snail對(duì)肝細(xì)胞癌(HepatocetlularCarcinoma，HCC)術(shù)后復(fù)發(fā)完整以病理結(jié)果結(jié)合影像學(xué)和術(shù)中情況確定；血清HBsAg、的研究一直是腫瘤研究的熱點(diǎn)。Snail蛋白是近年發(fā)現(xiàn)的鋅AFP水平以臨床檢