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1、國人順式阿曲庫銨的劑量反應(yīng)測定鄉(xiāng)一主鏖簽主壘盤!生!旦蔓12耋蔓!塑』皇竺!!!!』!塑!!!:!國人順式阿曲庫銨的劑量反應(yīng)測定陳錫萌杭燕南孫太金R}7?臨床研究?【擒■】目的采用經(jīng)典的單次注射法建立順式阿曲庫銨的劑量一反應(yīng)曲線,了解該肌松藥應(yīng)用于國人的量效關(guān)系,并確定其Eo,E…ED和ED值,為臨床研究和應(yīng)用提供參考.方琺ASAI～l綴揮期手術(shù)患者z4倒,隨機分為4組.咪唑安定,依托咪酯,芬太尼麻醉.4組病人分別單次靜注膊式阿曲庫銨0.02,0.03,0.04和0.05mg/kg,觀察拇指內(nèi)收肌四
2、十成串刺激(TOF)第一次反應(yīng)(T)最大抑制的百分率并進行概率單位轉(zhuǎn)換.將順式阿曲庫餓的首次劑量進行對效轉(zhuǎn)換,用直線回歸方法建立順式阿曲庫銨的劑量一反應(yīng)曲線.同時記錄起效時間.結(jié)果順式阿曲庫餓的ED,Ⅱ,Eo和Es的值分別為:0.03,0.039,0.049和0.056rag/ks.順式阿曲庫銨起艘時阿在四十劑量組之阿無顯著差異(P>O.05).結(jié)論國外文獻報道順式阿曲庫銨的ED值為0.o47～o.053rag/ks.本文得到的E值為0.O56mgtkg,與Sl外【關(guān)-調(diào)盎匿些要壁Themea
3、~arementofdoee-req=enserelationshipof~lsatracurluLmInChineseadultsWEND增,CHENXim,'ng,HANGYa,ma.teta1.DepartmentofAnesthesiology,Re.jiHospital,Shanghai嘶dMedicalU餓tsi.Shanghai200001[A]stract]ObjectiveToestablishthedose-responseCurveofcisarracuriumandtoeva
4、luatetheED,EDtEDandE5ofclsatracuriuminChineseaduhs.MetbedsTwenty-fourASAgradeI—lpatients,undergoingelectivesurgery,weredividedinto4groups.Anesthesiawasinducedwithmidazolam.etomldateandfentany1.EachoFfourgroupsoFpatientsreceivedintravenousbolusof0.02t0.
5、03,0.04or0.05rag/ksoFcisatracuriumrespectively.Theresponses1ⅣmdefinedintermsofthepercentagesofmaximumsuppressioninT1ofToFoFtheadductorpollicismuscle.Ac~ordiugtolog—probittransformationoFthedataofdoseandresponse.thedose—responsecurveOFcisatracur/umwases
6、tablishedthroughlinearregression.Theonsettimeofcisatrscurinmwflsalsoobserved.IhsultsTheED50.Ⅱ.ED,oandHoFcisatracuriumWere0.03t0.039,0.049and0.o56mg/kgrespec—tirely.Nosighi,cantchangeinonsettimeamong4groups.CmcluslenTheEDgsofcisa~raeufiuminChineseadI1lt
7、sissimi1attothatinothercountriesadu
8、ts.[Key'rd
9、】CisatracuriumDose—responserelationship.drug順式阿曲庫銨(cisatracurium)是阿曲庫銨(a—tracurium)的10種同分異構(gòu)體之一,約占混合物總量的15.國外研究表明,順式阿曲庫銨和阿曲庫銨具有相似的肌松效應(yīng)和代謝方式,其效能強于阿曲庫銨,而其組胺釋放和心血管反應(yīng)明顯低于阿曲庫銨,因而被認為是一種較有前途的新型非去極化肌松藥.本文采用單次注射法測定順
10、式阿曲庫銨在國人的量效關(guān)系,確定其EDEDED..和ED值,為該肌松藥的臨床研究和應(yīng)用提供參考.作者單位t200001上海第二醫(yī)科大學(xué)附屬仁井醫(yī)院麻辭辯資料和方法一般資料ASAI～I級肝腎功能正常,無神經(jīng)肌內(nèi)傳導(dǎo)疾病的擇期手術(shù)患者24倒,男性12倒,女性12伊J,年齡(40.3+8.7)歲,體重(61.6士9.8)kg.手術(shù)種類為腹部手術(shù)15倒,胸部手術(shù)4倒,顱腦手術(shù)3例,五官科手術(shù)2倒.24例患者按順式阿曲庫銨的首次給藥劑量分為4組,每組6例.所有患者術(shù)前均無酸堿平
