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1、婦癌考試解答Date:Sep.11,20061.針對(duì)上皮性卵巢癌,術(shù)後第一線化學(xué)治療(不管期別),請(qǐng)寫出五種混合式 化學(xué)治療處方(combinedchemotherapy),包括藥品,劑量,頻率,及療程cyclophosphamide(750mg/m2)+cisplatin(75mg/m2)(orcarboplatin)q3wx6coursescyclophosphamide(500mg/m2)+adriamycin(50mg/m2)+cisplatin(50mg/m2)q3wx6coursescarboplatin((AUC)of5-7.5)+paclitaxel(
2、175mg/m23-hrinfusion)q3wx6coursespaclitaxel(175mg/m2asa3-hourinfusion)+cisplatin(75mg/m2)q3wx6coursesdocetaxel(60-75mg/m21-hrinfusion)+carboplatin(AUCof5to6)q3wx6coursespaclitaxel(135mg/m2,IVfor24-hinfusionday1)+cisplatin(100mg/m2IP,day2)+paclitaxel(60mg/m2IP,day8(maxBSA2.0m2))q3wx6cour
3、ses2.針對(duì)下列婦癌疾病,最有效單一的化學(xué)藥物(singleactiveagent)為何?Uterinecerivcalcancer,SCC:CisplatinChoriocarcinoma:MTXUterineleiomyosarcoma:DoxorubicinUterineMMMT:Ifosfamide3.請(qǐng)問下列化療藥物各屬於何種類藥物？Etoposide:TopoisomeraseIIinhibitorEpirubicin:AntitumorantibioticsVincristin:VincaalkaloidCyclophosphamide:Alkylat
4、ingagentMethotrexate:Antimetabolics4.Cisplatinandpalcitaxel使用前應(yīng)注意事項(xiàng)及其pre-medicationCisplatinHematologictoxicityNephrotoxicityCCr<50ml/min,contraindicationtoCisplatin?carboplatinPrehydrationandposthydration,Diuretic(Lasix)GItoxicity(foremesis)Metoclopramide(primperan)Navoban(5H3serotonin
5、antagonist)NeurotoxicityPeripheralneuropathy?Vit.B(Hi-Bilox)4.Cisplatinandpalcitaxel使用前應(yīng)注意事項(xiàng)及其pre-medicationPaclitaxelPaclitaxel?Cisplatin,Cisplatin?PaclitaxolGItoxicity(foremesis)prochloperazine(Novamin)HypersensitivityreactionCorticosteroids(Decadron)H1blocker(Benamine)H2blocker(Tagam
6、et)Dipjenhydramine(Allermin)Cardiotoxicity(arrhythmia,bradycardia):EKGmonitorNeurotoxicityPeripheralneuropathy?Vit.B(Hi-Bilox)5.ifosphamide是屬於何種類化學(xué)藥物?有哪兩種比較特殊的毒性? 有何種化療保護(hù)劑(chemoprotectant),應(yīng)如何使用? 有那類婦癌疾病會(huì)應(yīng)用到ifosphamide來治療(請(qǐng)至少寫出兩種)AlkylatingagentToxicityHemorrhagiccystitisIfosfamidesyndr
7、omeMesnaDose:60-120%ofifosphamidetotaldosage3-day:400mg/m2IV,15-min,4-hr,8-hr,for3days24-hr:Halfoftotalmesnadose:divide6dosesQ4HRemaininghalfdose:divide2dosesQ6Hcervicalcancer,ovariancancer,anduterinesarcoma6.請(qǐng)問Adriamycin和Bleomycine各屬於何種類藥物?兩者都有致命的毒性(dose-limitingsideeffect)其致命
